ВОЗМОЖНОСТИ ФИТОТЕРАПИИ БОЛЕЗНИ АЛЬЦГЕЙМЕРА

  • Юрий Александрович Смирнов ФНИЦ эпидемиологии и микробиологии им. Н.Ф. Гамалеи Минздрава РФ
  • Татьяна Александровна Смирнова ФНИЦ эпидемиологии и микробиологии им. Н.Ф. Гамалеи Минздрава РФ
  • Залина Султановна Плиева ФНИЦ эпидемиологии и микробиологии им. Н.Ф. Гамалеи Минздрава РФ
  • Владимир Григорьевич Жуховицкий ФНИЦ эпидемиологии и микробиологии им. Н.Ф. Гамалеи Минздрава РФ
Ключевые слова: болезнь Альцгеймера, бета-амилоид (Aβ), лекарственные растения, биологически активные вещества

Аннотация

Болезнь Альцгеймера является нейродегенеративным заболеванием мозга, причиной повреждения памяти и нарушений социального поведения человека. Болезнь Альцгеймера в настоящее время является неизлечимым заболеванием, поэтому поиски новых средств лечения этой болезни являются весьма актуальными. Наряду с разработкой новых синтетических препаратов проводятся изыскания веществ растительного происхождения. В обзоре приведены общие сведения о болезни Альцгеймера, обобщены научные данные об активности растительных лекарственных средств. Рассматриваются механизмы действия биологически активных веществ лекарственных растений.

Биографии авторов

Юрий Александрович Смирнов, ФНИЦ эпидемиологии и микробиологии им. Н.Ф. Гамалеи Минздрава РФ

Д.м.н., профессор, ведущий научный сотрудник лаборатории онтогенеза вирусов

Татьяна Александровна Смирнова, ФНИЦ эпидемиологии и микробиологии им. Н.Ф. Гамалеи Минздрава РФ

Д.б.н., ведущий научный сотрудник лаборатории индикации и ультраструктурного анализа микроорганизмов

Залина Султановна Плиева, ФНИЦ эпидемиологии и микробиологии им. Н.Ф. Гамалеи Минздрава РФ

Младший научный сотрудник лаборатории индикации и ультраструктурного анализа микроорганизмов

Владимир Григорьевич Жуховицкий, ФНИЦ эпидемиологии и микробиологии им. Н.Ф. Гамалеи Минздрава РФ

К.м.н., руководитель лаборатории индикации и ультраструктурного анализа микроорганизмов

Литература

Большой энциклопедический словарь лекарственных растений. – СПб.: СпецЛит, 2015.

Рекстина В.В., Горковский А.А., Безсонов Е.Е., Калебина Т.С. Амилоидные белки поверхности микроорганизмов: структура, свойства и значение для медицины // ВЕСТНИК РГМУ. 1, 2016. – С.4–13.

Смирнов Ю.А., Киселева Т.Л., Смирнова Ю.А., Карпеев А.А. Подходы к антивирусной фитотерапии // Традиционная медицина. – 2009. – №2(17). – С.47–59.

Akhondzadeh S., Noroozian M., Mohammadi M., Ohadinia S., Jamshidi A.H., Khani M. et al. Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer’s disease: a double blind, randomised, placebo controlled trial // J. Neurol., Neurosurg. Psychiatry. – 2003; 74: 863–866.

Allison A.C., Cacabelos R., Lombardi V.R.M., Alvarez X.A., Vigo C. Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alziemier’s disease // NeuroPsychopharmacol. & Biol. Psychiat. – 2001; 25: 1341–1357.

Anekonda T.S., Hemachandra Reddy P. Can herbs provide a new generation of drugs for treating Alzheimer’s disease? // Brain Research Reviews. – 2005; 50: 361–376.

Asai M., Iwata N., Yoshikawa A., Aizaki Y., Ishiura S. Berberine alters the processing of Alzheimer’s amyloid precursor protein to decrease Ab secretion // Biochemical and Biophysical Research Communications. – 2007; 352: 498–502.

Ballard C., Gauthier S., Corbett A., Brayne C., Aarsland D., Jones E. Alzheimer’s disease // The Lancet. – 2011. – Vol. 377. – P.1019–1031.

Baohua Cao, Yan Zhao, Yongjun Koua, Dongchun Ni, Xuejun Cai Zhang and Yihua Huang Structure of the nonameric bacterial amyloid secretion channel // PNAS, 2014 111 (50). E5439–E5444.

Barnhart M.M., Chapman M.R. Curli biogenesis and function // Annu Rev Microbiol; 2006, 60: 131–147.

Bent S., Ko R. Commonly Used Herbal Medicines in the United States: A Review // The American Journal of Medicine. – 2004; 116: 481.

Berchtold N.C., Cotman C.W. (1998). «Evolution in the conceptualization of dementia and Alzheimer’s disease: Greco-Roman period to the 1960s» // Neurobiol. Aging. 19 (3): 173–89.

Brookmeyer R., Johnson E., Ziegler-Graham K., Arrighi HM (July 2007). «Forecasting the global burden of Alzheimer’s disease» // Alzheimer’s and Dementia. 3(3): 186–91.

Burokas A., Moloney R.D., Dinan T.G. et al. Microbiota regulation of the mammalian gut – brain axis // Adv Appl Microbiol. – 2015; 91: 1–62.

Cashman J.R., Ghirmai S., Abel K.J., Fiala M. Immune defects in Alzheimer’s disease: new medications development // BMC Neuroscience. 2008. – Vol. 9, suppl. 2. – P.S13.

Chang Ho C., Kumaran A., Hwang L.S. Bio-assay guided isolation and identification of antiAlzheimer active compounds from the root of Angelica sinensis // Food Chemistry. – 2009; 114: 246–252.

Chang R.C.C., So K.F. Use of anti-aging herbal medicine, Lycium barbarum, against agingassociated diseases. What do we know so far? // Cell Mol. Neurobiol. –

; 28: 643–652.

Chen F., Eckman E.A., Eckman C.B. Reductions in levels of the Alzheimer’s amyloid beta peptide after oral administration of ginsenosides // FASEB J. – 2006; 20: 1269–1271.

Claudio L., Ultrastructural features of the blood-brain barrier in biopsy tissue from Alzheimer’s disease patients // Acta Neuropathol. – 91 (1996) 6–14.

Das A., Shanker G., Nath C., Pal R., Singh S., Singh H. et al. A comparative study in rodents of standardized extracts of Bacopa monniera and Ginkgo biloba: anticholinesterase and cognitive enhancing activities // Pharmacology, Biochemistry and Behavior. – 2002; 73: 893–900.

Dhuley J.N. Nootropic-like effect of ashwagandha (Withania somnifera L) in mice // Phytotherapy Research. – 2001; 15: 524–528.

Farrall A.J., Wardlaw J.M. Blood-brain barrier: Ageing and microvascular disease – systematic review and meta-analysis. // Neurobiol. Aging (2007).

Ha J.H., Lee D.U., Lee J.T., Kim J.S., Yong C.S., Kim J.A. et al. 4-Hydroxybenzaldehyde from Gastrodia elata B1 is active in the antioxidation and GABAergic neuromodulation of the rat brain // Journal of Ethnophamacology. – 2000; 73: 329–333.

Hardy J., Allsop D. (1991). «Amyloid deposition as the central event in the aetiology of Alzheimer’s disease» // Trends Pharmacol. Sci. 12(10): 383–88.

Hellstrom-Lindahl E., Court J., Keverne J., Svedberg M., Lee M., Marutle A. et al. Nicotine reduces A beta in the brain and cerebral vessels of APPsw mice // Eur. J. Neurosci. – 2004; 19: 2703–2710.

Hill J.M., Clement C., Pogue A.I., Bhattacharjee S., Zhao Y., Lukiw W.J. Pathogenic microbes, the microbiome, and Alzheimer’s disease (AD) // Front Aging Neurosci. – 2014 Jun 16; 6: 127.

Hsieh M.T., Tsai F.H., Lin Y.C., Wang W.H., Wu C.R. Effects of ferulic acid on the impairment of inhibitory avoidance performance in rats // Planta Medica. – 2002; 68: 754–756.

Ho Y.S. Anti-aging herbal medicine-how and why can they be used in aging associated neurodegenerative diseases? // Ageing Res. Rev. – 2009; doi: 10.1016.

Ichikawa H., Wang X., Konishi T. Role of component herbs in antioxidant activity of shengmai san: a traditional Chinese medicine formula preventing cerebral oxidative damage in rat // American Journal of Chinese Medicine. – 2003; 31: 509–521.

Irie Y., Keung W.M. Rhizoma acori graminei and its active principles protect PC-12 cells from the toxic effect of amyloid-beta peptide // Brain Res. – 2003; 963: 282–289.

Jang J.H., Surh Y.J. Protective effect of resveratrol on beta-amyloid induced oxidative PC-12 cell death. – Free Radical Biol. Med. – 2003; 34: 1100–1110.

Jia H., Jiang Y., Ruan Y., Zhang Y., Ma X., Zhang J. et al. Tenuigenin treatment decreases secretion of the Alzheimer’s disease amyloid betaprotein in cultured cells // Neurosci. Lett. – 2004; 367: 123–128.

Joo S.S., Yoo Y.M., Ahn B.W., Nam S.Y., Kim Y.B., Hwang K.W. et al. Prevention of inflammation mediated neurotoxicity by Rg3 and its role in microglial activation // Biol. Pharm. Bull. – 2008; 31: 1392–1396.

Kalaria R.N., Maestre G.E., Arizaga R., Friedland R.P., Galasko D., Hall K. et al. Alzheimer’s disease and vascular dementia in developing countries: prevalence, management, and risk factors // Lancet Neurol. –2008; 7: 812–826.

Khalifa A.E. Hypericum perforatum as a nootropic drug: enhancement of retrieval memory of a passive avoidance conditioning paradigm in mice // J. of Ethnophamacology. – 2001; 76; 49–57.

Kim H.J., Moon K.D., Lee D.S., Lee S.H. Ethyl ether fraction of Gastrodia elata Blume protects amyloid beta peptideinduced cell death // Journal of Ethnophamacology. – 2003; 84: 95–98.

Klusa V., Germane S., Noldner M., Chatterjee S.S. Hypericum extract and hyperforin: memoryenhancing properties in rodents // Pharmacopsychiatry. – 2001; 34: S61–S69.

Kulkarni S., Dhir A., Akula K.K. Potentials of curcumin as an antidepressant // Scientific World Journal. – 2009. – №9. – P.1233–1241.

Kumar V., Singh P.N., Muruganandam A.V., Bhattacharya S.K. Effect of Indian Hypericum perforatum Linn on animal models of cognitive dysfunction // Journal of Ethnophamacology. – 2000; 72: 119–128.

LeBars P.L., Katz MM, Berman N. A placebo controlled, doubleblind, randomized trial of an extract of Ginkgo biloba for dementia // JAMA. – 1997; 278: 1327–1332.

Leclerc S., Garnier M., Hoessel R., Marko D., Bibb J.A., Snyder G.L. et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer’s disease. A property common to most cyclindependent kinase inhibitors // J. Biol. Chem. – 2001; 276: 251–260.

Li M.D., Kane J.K., Matta S.G., Blaner W.S., Sharp B.M. Nicotine enhances the biosynthesis and secretion of transthyretin from the choroid plexus in rats: implications for beta-amyloid formation // J. Neurosci. – 2000; 20: 1318–1323.

Lin Y.C., Wu C.R., Lin C.J., Hsieh M.T. The ameliorating effects of cognition-enhancing Chinese herbs on scopolamine and MK-801-induced amnesia in rats // American Journal of Chinese Medicine. – 2003; 31: 543–549.

Liu J,. Mori A. Antioxidant and pro-oxidant activities of p-hydroxybenzyl alcohol and vanillin: effects on free radicals, brain peroxidation and degradation of benzoate, deoxyribose, amino acids and DNA // Neuropharmacology. – 1993; 32: 659–669.

Lopez S., Bastida J., Viladomat F., Codina C. Acetylcholinesterase inhibitory activity of some Amaryllidaceae alkaloids and Narcissus extracts // Life Sciences. –

; 71: 2521–2529.

Luo Y. Alzheimer’s disease, the nematode Caenorhabditis elegans, and Ginkgo biloba leaf extract // Life Sci. – 2006; 78: 2066–2072.

McCrate O.A., Zhou X., Cegelski L. Curcumin as an amyloid-indicator dye in E. coli // Chem Commun (Camb). – 2013 V. 49, 4193–4195.

Mohamed A.F., Matsumoto K., Tabata K., Kitjima M., Watanabe H. et al. Effects of Uncariatomentosa total alkaloid and its components on experimental amnesia in mice: elucidation using the passive avoidance test // The Journal of Pharmacy and Pharmacology. – 2000; 52: 1553–1561.

Mudher A., Lovestone S. (2002). «Alzheimer’s disease-do tauists and baptists finally shake hands?» // Trends Neurosci. 25 (1): 22–26.

Neish A.S. Microbes in gastrointestinal health and disease // Gastroenterol. – 2009. 136: 65–80.

Nishiyama N., Chu P.J., Saito H. Beneficial effects of biota, a traditional Chinese herbal medicine on learning impairment induced by basal forebrain-lesion in mice // Biological and Pharmaceutical Bulletin. – 1995; 18: 1513–1517.

Nordberg A., Hellstrom-Lindahl E., Lee M., Johnson M., Mousavi M., Hall R. et al. Chronic nicotine treatment reduces beta-amyloidosis in the brain of a mouse model of Alzheimer’s disease (APPsw) // J. Neurochem. – 2002; 81: 655–658.

Oken B.S., Storzbach D.M., Kaye J.A. The efficacy of Ginkgo biloba on cognitive function in Alzheimer disease // Arch Neurol. – 1998; 55: 1409–1415.

Ott B.R., Owens N.J. Complementary and alter-native medicines for Alzheimer’s disease // Journal of Geriatric Psychiatry and Neurology. – 1998; 11: 163–173.

Park C.H., Choi S.H., Koo J.W., Seo J.H., Kim H.S., Jeong S.J. et al. Novel cognitive improving and neuroprotective activities of Polygala tenuifolia Willdenow extract, BT-11 // Journal of Neuroscience Research. – 2002; 70: 484–492.

Park C.H., Kim S.H., Choi W., Lee Y.J., Kim J.S., Kang S.S. et al. Novel anticholinesterase and antiamnesic activities of dehydroevodiamine, a constituent of Evodia rutaecarpa // Planta Medica. – 1996; 62: 405–409.

Pistollato F., Sumalla S. Cano, Elio I., Masias M., Vergara Giampieri F. and Battino M. Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease // Nutrition reviews. – 2016, 74(10):624–634.

Qian Y.H., Liu Y., Hu H.T., Ren H.M., Chen X.L., Xu J.H. et al. The effects of the total saponin of Dipsacus asperoides on the damage of cultured neurons induced by beta-amyloid protein 25–35 // Anatomical Science International. – 2002; 77: 196–200.

Rai K.S., Murthy K.D., Karanth K.S., Rao M.S. Clitoria ternatea (Linn) root extract treatment during growth spurt period enhances learning and memory in rats // Indian Journal of Pharmacology. – 2001; 45: 305–313.

Reichhardt C., Jacobson A.N., Maher M.C., Uang J., McCrate O.A., Eckart M., Cegelski L. Congo Red Interactions with Curli-Producing E. coli and Native Curli Amyloid Fibers. PLOS ONE | DOI:10.1371/journal.pone.0140388 October 20, 2015.

Russo A., Palumbo M., Aliano C., Lempereur L., Scoto G., Renis M. et al. Red wine micronutrients as protective agents in Alzheimer like induced insult // Life Sci. – 2003; 72: 2369–2379.

Sasaki H., Sunagawa Y., Takahashi K., Imaizumi A., Fukuda H., Hashimoto T. et al. Innovative preparation of curcumin for improved oral bioavailability // Biol Pharm Bull. – 2011; 34(5):660–665.

Sassa H., Takaishi Y., Terada H. The Triterpene Celastrol is a Very Potent Inhibitor of Lipid Peoxidation in Mitochondria // Biochem. Biophys. Res. Comm. – 1990; 172: 890–897.

Shen Z.X. (2004). «Brain cholinesterases: II. The molecular and cellular basis of Alzheimer’s disease» // Med. Hypotheses. – 63(2): 308–21.

Sinclair S. Chinese herbs: a clinical review of Astragalus, Ligusticum, and Schizandrae // Alternative Medicine Review. – 1998; 3: 338–344.

W. Small G., Siddarth P., Zhaoping Li, Miller K.J., Ercoli L., Emerson N.D., Martinez J., Wong K.-P., Liu J., Merrill D.A., Chen S.T., Satyamurthy N., Huang S.-C., Heber D., Barrio J.R. Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial // Am J Geriatr Psychiatry. – 2018. Mar 27; 26(3):266–277.

Smith J.V., Luo Y. Studies on molecular mechanisms of Ginkgo biloba extract // Appl. Microbiol. Biotechnol. – 2004; 64; 465–472.

Tang M., Taghibiglou Ch. The Mechanisms of Action of Curcumin in Alzheimer’s Disease // J. Alzheimers Dis. – 2017, vol. 58, no. 4, pp. 1003–1016.

Toda S., Yase Y., Shirataki Y. Inhibitory effects of astragali radix, crude drug in Oriental medicines on lipid peroxidation and protein oxidative modification of mouse brain homogenate by copper // Phytotherapy Research. – 2000; 14: 294–296.

Touqeer Ahmed, Anwar-ul Hassan Gilani. Therapeutic Potential of Turmeric in Alzheimer’s Disease: Curcumin or Curcuminoids? // Phytother Res. – 2014. Apr;28(4):517–25.

Veerendra Kumar M.H., Gupta Y.K. Effect of Centella asiatica on cognition and oxidative stress in an intracerebroventricular streptozotocin model of Alzheimer’s disease in rats // Clin. Exp. Pharmacol. Physiol. –2003; 30: 336–342.

Vohora D., Pal S.N., Pillai K.K. Protection from phenytoin-induced cognitive deficit by Bacopa monniera, a reputed Indian nootropic plant // Journal of Ethnophamacology. – 2000; 71: 383–390.

Weiss N., Miller F., Cazaubon S., Couraud P.O. The blood-brain barrier in brain homeostasis and neurological diseases // Biochim Biophys Acta. – 2009. – №1788. – P. 842–857.

Westmoreland S.V., Rottman J.B., Williams K.C., Lackner A.A., Sasseville V.G., Chemokine receptor expression on resident and inflammatory cells in the brain of macaques with simian immunodeficiency virus encephalitis // Am. J. Pathol. – 152 (1998) 659–665.

Yang F., Lim G.P., Begum A.N., Ubeda O.J., Simmons M.R., Ambegaokar S.S. et al. Curcumin inhibits formation of amyloid {beta} oligomers and fibrils, binds plaques, and reduces amyloid in vivo // J. Biol. Chem. – 2005; 280: 5892–5901.

Yu M.S., Lai C.S., Ho Y.S., Zee S.Y., So K.F., Yuen W.H. et al. Characterization of the effects of anti-aging medicine Fructus lycii on betaamyloid peptide neurotoxicity // Int. J. Mol. Med. – 2007; 20: 261–268.

Zangara A. The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer’s disease // Pharmacology, Biochemistry and Behavior. – 2003; 75: 675– 686.

Zhang Z.J., Qian Y.H., Hu H.T., Yang J., Yang G.D. The herbal medicine Dipsacusasper wall extract reduces the cognitive deficits and over expression of beta-amyloid protein induced by aluminum exposure // Life Sciences. – 2003; 73: 2443–2454.

Zhang Z.J. Therapeutic effects of herbal extracts and constituents in animal models of psychiatric disorders // Life Sciences. – 2004; 75: 1659–1699.

Zhao Y., Lukiw W.J. 2015. Microbiome-generated amyloid and potential impact on amyloidogenesis in Alzheimer’s disease (AD) // J. Nat Sci. V.1, N7: e138.

Опубликован
2018-12-31
Как цитировать
[1]
Ю. А. Смирнов, Т. А. Смирнова, З. С. Плиева, и В. Г. Жуховицкий, «ВОЗМОЖНОСТИ ФИТОТЕРАПИИ БОЛЕЗНИ АЛЬЦГЕЙМЕРА», Научно-практический журнал, вып. 4(55) 2018, сс. 20-28, дек. 2018.
Выпуск
Раздел
Натуротерапия