Results of experimental studies of plant extract on model of toxic damage of the liver in the experiment on animals

Authors

  • E.V. Ferubko All-Russian scientific research institute of Medicinal and Aromatic plants
  • S.M. Nikolaev Laboratory of experimental pharmacology of General and Experimental Institute of Biology, Siberian branch of RAS
  • T.D. Dargaeva All-Russian scientific research Institute of Medicinal and Aromatic plants

Keywords:

plant extract, toxic hepatitis, hepatoprotective action

Abstract

Results of studying of hepatoprotective effect of the multicomponent plant extract received from the following types of plant raw materials: sandwort flowers, tansy flowers, rose hips, dioecious nettle leaves, mint leaves, licorice roots in the conditions of model of toxic hepatitis are provided.
It is established that course introduction of per os of extract in a dose of 250 mg/kg to white nonlinear rats with toxic injury of a liver has hepatoprotective effect, somewhat exceeding effect of drug of comparison of Allocholum.
Results of the conducted researches demonstrated that pharmacotherapy of toxic hepatitis with plant extract significantly decreases levels of activity of enzymes in blood serum – cytolysis syndrome markers, lowers manifestations of cholestasia syndrome.
Pharmacoterapeutic influence of extract on damaged liver is caused by existence of a complex in it of biologically active agents and, first of all, components of the phenolic nature. The results of research suggest use of the plant extract containing biologically active agents of the phenolic nature in complex treatment and prevention of diseases of a liver.

Author Biographies

E.V. Ferubko, All-Russian scientific research institute of Medicinal and Aromatic plants

Ph. D. (Med.), Head of department of experimental and clinical pharmacology of the Center of Medicine

S.M. Nikolaev, Laboratory of experimental pharmacology of General and Experimental Institute of Biology, Siberian branch of RAS

Dr. Sc. (Med.), prof., Chief researcher of Laboratory of experimental pharmacology

T.D. Dargaeva, All-Russian scientific research Institute of Medicinal and Aromatic plants

Dr. Sc. (Pharm.), prof., Chief researcher of Department of standardization and certification

References

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Традиционная медицина № 3 (58) 2019

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Published

2019-09-30

How to Cite

Ferubko Е. В., Nikolaev С. М., and Dargaeva Т. Д. “Results of Experimental Studies of Plant Extract on Model of Toxic Damage of the Liver in the Experiment on Animals”. Traditional Medicine, no. 3(58) 2019, Sept. 2019, pp. 45-49, http://www.tradmed.ru/index.php/tm/article/view/1466.

Issue

No. 3(58) 2019

Section

Naturopathy

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