Prospects of using chest berry (Vitex agnus-castus L.) as a source of obtaining medicines

(OVERVIEW)

Authors

  • Г. В. Адамов FSBSI VILAR
  • О. Л. Сайбель FSBSI VILAR
  • Т. Д. Даргаева FSBSI VILAR

Keywords:

Vitex agnus-castus, chaste berry, biologically active substances, pharmacological properties

Abstract

At present, the use of medicinal plants for soft influence on hormonal disorders of the female reproductive system remains relevant. It has long been noted that Vitexagnus-castus is able to exert physiological effects similar to that of sex hormones, such as reducing male libido and alleviating the symptoms of female mastalgia. The dopaminergic activity of Vitexagnus-castusL. was proved and the possibility of influencing the opioid system was also described in the literature. It is also able to provide antimicrobial, anti-inflammatory, anti-carcinogenic action and also affect cognitive functions due to various classes of secondary metabolites of Vitex agnus-castus, such as flavonoids, iridoids, terpenoids.

Author Biographies

  • Г. В. Адамов, FSBSI VILAR

    Adamov G. V., graduate student FSBSI VILAR

  • О. Л. Сайбель, FSBSI VILAR

    O.L. Saybel, , Head of the Department of Standardization FSBSI VILAR, Candidate of Pharmaceutical Sciences

  • Т. Д. Даргаева, FSBSI VILAR

    Dargaeva Т.D., Chief Scientific Officer of the Department of Standardization FSBSI VILAR, Doctor of Pharmaceutical Sciences, Professor

References

Abeer Y. Ibrahim, Samah A. El-Newary, Eman R. Youness, Amr M.M. Ibrahim, Walaa A. El Kashak. Protective and therapeutic effect of Vitexagnus-castus against prostate cancer in rat // Journal of Applied Pharmaceutical Science Vol. 7 (12), pp. 133-143, December, 2017.

Торшин И.Ю., Громова О.А., Лиманова О.А. Систематический анализ состава и механизмов молекулярного воздействия стандартизированных экстрактов Vitex Agnus-castus // Трудный пациент. – 2015. - №1-2. – т.13. – С.19–28.

Высоцкая И.В., Летягин В.П. Фармакологические эффекты и молекулярные механизмы действия лечебного фитопрепарата на основе Vitex agnus-castus // Маммология. – 2017. – №1. – том 13. – С.14–19.

Вуттке В., Ярри Г., Зайдлова-Вуттке Д., Уварова Е.В., Девятченко Т.Ф., Гуменюк Е.Г., Погодин О.К., Левенец С.А. Терапевтические возможности экстрактов из Авраамова дерева (Vitex Agnus-castus) в гинекологической практике // Проблемы репродукции. – 2009. – №4. – С.53–58.

Замотайлов А.С., Литвинская С.А. Красная книга Краснодарского края. – 2007.

Лавренов В.К., Лавренова Г.В. Энциклопедия лекарственных растений народной медицины. – СПб.: Издательский дом «Нева», 2003 – 46 с.

Mohamed Latoui, Bahar Aliakbarian, Alessandro A. Casazza, Mongi Seffen, Attilio Converti, Patrizia Perego. Extraction of phenolic compounds from Vitexagnus-castus L. // Food and Bioproducts Processing, October 2012, Pages 748–754.

German homoeopathic pharmacopoeia, 2003 Medpharm Scientific Publishers, Stuttgart, Germany.

European Pharmacopoeia 9.0.

Upton Roy. American herbal pharmacopoeia.American Herbal Pharmacopoeia, 2011.

Chen Shao-Nong et al. Phytoconstituentsfrom Vitexagnus-castus fruits.Fitoterapia 82.4 (2011): 528–533.

Ajay Kumar Meena, Niranjan U.S., Rao M.M., Padhi M.M., Ramesh Babu. A review of the important chemical constituents and medicinal uses of Vitex genus // Asian Journal of Traditional Medicines, 2011, 6 (2). – Р.54–60.

Stojković Dejan et al. Chemical composition and antimicrobial activity of Vitexagnus-castus L. fruits and leaves essential oils. Food Chemistry 128.4 (2011): 1017-1022.

Hayder B. Sahib, Adeeb A. AL-Zubaudy, Shallal M. Hussain, Ghaith Ali Jasim, Ban J. Qasim, sawsan S. Al Rawi Acute Toxicity of Vitexagnuscastus Methanol Extract // Int. J. Pharm. Sci. Rev. Res., 26(2), May – Jun 2014; Article No. 22, Pages: 123–128/

Ramírez-Cisneros M.Á. et al. In vitro COX-1 and COX-2 enzyme inhibitory activities of iridoids from Penstemonbarbatus, Castillejatenuiflora, Cresentiaalata and Vitexmollis // Bioorganic & medicinal chemistry letters. – 2015. – Т. 25. – №. 20. – С.4505–4508.

Bas Esperanza et al. Inhibition of the pro-inflammatory mediators’ production and anti-inflammatory effect of the iridoidscrovalentinoside // Journal of ethnopharmacology 110.3 (2007): 419–427.

Sundaram R. et al. Antihyperglycemic effect of iridoid glucoside, isolated from the leaves of Vitexnegundo in streptozotocin-induced diabetic rats with special reference to glycoprotein components //Phytomedicine. – 2012. – Т. 19. – №. 3. – С. 211–216.

Kuruüzüm-Uz Ayşe et al. Glucosides from Vitexagnus-castus.Phytochemistry 63.8 (2003): 959–964.

Li Shenghong et al. Compounds from the fruits of the popular European medicinal plant Vitexagnus-castus in chemoprevention via NADP (H): Quinone oxidoreductase type 1 induction. Evidence-Based Complementary and Alternative Medicine 2013 (2013).

Hoberg Eva et al. Diterpenoids from the fruits of Vitex agnus-castus // Phytochemistry 52.8 (1999): 1555–1558.

Jarry Hubertus et al. In vitro assays for bioactivity-guided isolation of endocrine active compounds in Vitex agnus-castus.Maturitas 55 (2006): S26–S36.

Mari Angela et al. Metabolic profiling of Vitexagnuscastus leaves, fruits and sprouts: Analysis by LC/ESI/(QqQ) MS and (HR) LC/ESI/(Orbitrap) / MS n. Journal of pharmaceutical and biomedical analysis 102 (2015): 215-221.23. 10.1016/j.phymed.2012.08.006.

Schellenberg R., Zimmermann H.R., Drewe J. Дозозависимая эффективность экстракта Vitex agnus-castus ZE 440 у пациенток с предменструальным синдромом // Репродуктивная эндокринология. – 2016. – №4 (30). – С.111–118.

Yong-Jiang Li, Xiong-Bin Hu, Xiu-Ling Lu, De-Hua Liao, Tian-Tian Tang, Jun-Yong Wu, Da-Xiong Xiang. (2017) Nanoemulsion-based delivery system for enhanced oral bioavailability and Caco-2 cell monolayers permeability of berberine hydrochloride. Drug Delivery 24:1, pages 1868–1873/

Allahtavakoli, Mohammad et al. Vitexagnuscastus extract improves learning and memory and increases the transcription of estrogen receptor α in hippocampus of ovariectomized rats. // Basic and clinical neuroscience 6.3 (2015): 185.

Zahid Hina, Ghazala H. Rizwani and Sumaira Ishaqe. Phytopharmacological review on Vitex agnus-castus: a potential medicinal plant. // Chinese Herbal Medicines 8.1 (2016): 24–29.

Vitex agnus-castus. Monograph/ Alternative Medicine Review Volume 14, Number 1 2009.[Электронный ресурс] – Режим доступа: http://www.altmedrev.com/publications/14/1/67.pdf. [Дата обращения 29.12.2017].

Vitex agnus-castus. A Systematic Review of Adverse Events/ Claudia Daniele Joanna Thompson CoonMax H. PittlerEdzardErnst // Drug SafetyApril 2005, Volume 28, Issue 4, pp 319–332.

Horrobin D.F. Prolactin: physiology and clinical significance/ Horrobin D. F. – Lancaster: MTP Press Ltd., 1973 – p.503–507].

Wuttke W. et al. Chaste tree (Vitexagnus-castus)–pharmacology and clinical indications. Phytomedicine 10.4 (2003): 348–357.

Артымук Н.В., Устинова Т.А., Власова В.В. Опыт применения Vitex Agnus-castus в комплексе лечения пациенток с синдромом поликистозных яичников и бесплодием // Российский вестник Акушера-гинеколога. – 2011. – №2. – С.65–68.

Webster D.E. et al. Activation of the μ-opiate receptor by Vitexagnus-castus methanol extracts: Implication for its use in PMS. Journal of ethnopharmacology 106.2 (2006): 216–221.

Kilicdag E.B. et al. Fructusagnicasti and bromocriptine for treatment of hyperprolactinemia and mastalgia // International Journal of Gynecology & Obstetrics 85.3 (2004): 292–293.

Schulte P. et al. The treatment of premenstrual syndrome with preparations of Vitex Agnus-castus (Chaste-berry): A systematic review and meta-analysis // European Psychiatry 41 (2017): S907–S908.

Sarac Nurdan, Aysel Ugur and Burak Sen. In vitro antimutagenic activity of Vitexagnus-castus L. essential oils and ethanolic extracts. Industrial Crops and Products 63 (2015): 100–103.

Bashir Ahmad, Sadiq Azam, Shumaila Bashir, Achyut Adhikari and Iqbal Choudhary M. Biological activities of a new compound isolated from the aerial parts of Vitexagnuscastus L. // African Journal of Biotechnology Vol. 9(53), pp. 9063–9069, 27 December, 2010.

Antifungal activity of Vitexagnuscastus-in vitro study / G. MOHANDASS, K. SUGUNA DEVI and AMALORPAVARA // Biomedical & Pharmacology Journal Vol. 3(1), 187–190 (2010)/

Švecová E. et al. Antifungal activity of Vitex agnus-castus extract against Pythium ultimum in tomato. Crop protection 43 (2013): 223–230.

Stojković Dejan et al. Chemical composition and antimicrobial activity of Vitex agnus-castus L. fruits and leaves essential oils // Food Chemistry 128.4 (2011): 1017–1022.

Значение прутняка обыкновенного в гинекологической эндокринологии / Источник: Wuttke W., Seidlova-Wuttke D., Jarry H., Artymuk N. Der Stellenwert des Monchspfeffers (Vitex agnus-castus). Zeitschriftfur Phytotherapie 2010; 31: 294–298. Пер. Михаил Фирстов // Репродуктивная эндокринология. – 2013. – №1 (9). – С.58–62.

Downloads

Published

2018-03-31

Issue

Section

Naturopathy

How to Cite

“Prospects of Using Chest Berry (Vitex Agnus-Castus L.) As a Source of Obtaining Medicines: (OVERVIEW)”. Traditional Medicine, no. 1(52) 2018, Mar. 2018, pp. 28-33, https://www.tradmed.ru/index.php/tm/article/view/1403.

Most read articles by the same author(s)