Location in nature, cell cultures, application and pharmacological action of betalains and their derivatives
Keywords:
betalains, pigments, alkaloids, application, pharmacological actionAbstract
Data on some natural sources of alkaloids-pigments of betalaines class and their derivatives, pharmacological action and application are provided.
References
Gandia-Herrero, F. Biosynthesis of betalains: yellow and violet plant pigments / F. Gandia-Herrero, F. Garcia-Carmona // Trends Plant Sci. – 2013. – Vol.18. – P.334–343.
Polturak, G. «La Vie en Rose»: Biosynthesis, Sources, and Applications of Betalain Pigments / G. Polturak, A. Aharoni // Molecular Plant. – 2018. – Vol.11. – Is 1. – P.7–22.
Light-induced betacyanin and flavonol accumulation in bladder cells of Mesembryanthemum crystallinum / T. Vogt, M. Ibdah, J. Schmidt [et al.] // Phytochemistry. – 1999. – Vol. 52. – Is. 4. – P.583–592.
Khan, M.I. Plant betalains: Chemistry and biochemistry / M.I. Khan, P. Giridhar // Phytochemistry. – 2015. – Vol.117. – P.267–295.
Саенко, И.И. Получение сухих форм бетацианинов свеклы / И.И. Саенко, Л.А. Дейнека, В.И. Дейнека // Известия вузов. Прикладная химия и биотехнология. – 2012. – N 2 (3). – C.177–179.
Влияние рН среды на концентрацию беталаиновых пигментов растительного происхождения / Д.И. Валеева, Х. Саттиходжаев, К.Ю. Швинк [и др.] // Научное обозрение. Фундаментальные и прикладные исследования. – 2019. – №2.; URL: http://www.scientificreview.ru/ru/article/view?id=58
Radfar, M. Betalains from stem callus cultures of Zaleya decandra L. N. Burm. f. A medicinal herb / M. Radfar, M.S. Sudarshana, M.H. Niranjan // J. Med. Plants Res. – 2012. – Vol.6. – N12. – P.2443–2447.
Reznik, H. Investigations on the betalain pigments of the aizoaceae i. the betaxanthins of the ruschieae / H. Reznik, U. Engel, C. Wambach // Beitraege zur Biologie der Pflanzen. – 1988. – Vol.63. – N.(1-2). – P.209–220.
Strack, D. Recent Advances in Betalain Research / D. Strack, T. Vogt, W. Schliemann // Phytochemistry. – 2003. – Vol. 62. – P.247–69.
Light-induced betacyanin and flavonol accumulation in bladder cells of Mesembryanthemum crystallinum / T. Vogt, M. Ibdah, J. Schmidt [et al.] // Phytochemistry. – 1999. – Vol. 5. – Is.4. – P.583–592.
Impellizzeri, G. A new betaxanthin from Glottiphyllum longum / G. Impellizzeri, M. Piattelli, S. Sciuto // Phytochemistry. – 1973. – Vol.12. – P.2293–2294.
Biological effects of red beetroot and betalains: A review / E. Hadipour, A. Taleghani, N. Tayarani-Najaran [et al.] // Phytother Res. 2020 Mar 14. doi: 10.1002/ptr.6653.
Miguel, M.G. Betalains in Some Species of the Amaranthaceae Family: A Review / M.G. Miguel // Antioxidants (Basel). 2018. – Vol.7. – N4. – pii: E53.
Sarker, U. Nutrients, minerals, antioxidant pigments and phytochemicals, and antioxidant capacity of the leaves of stem amaranth / U. Sarker, S. Oba, M.A. Daramy // Sci Rep. – 2020. – Vol.10. – N.1. – P.3892.
Betacyanins and phenolic compounds from Amaranthus spinosus L. and Boerhavia erecta L. / F.C. Stintzing, D. Kammerer, A. Schieber [et al.] // Z Naturforsch C J Biosci. – 2004. – Vol. 59. – N1–2. – P.1–8.
Betalains and phenolic compounds of leaves and stems of Alternanthera brasiliana and Alternanthera tenella / L. Deladin, I. Alvarez, B. De Ancos [et al.] // Food Res Int. – 2017. – Vol.97. – P.240–249.
Production of pigments in Alternanthera sessilis calli mediated by plant growth regulators and light. / C. Milech, S. Lucho, A. Kleinowski [et al.] // Acta Scientiarum. Biol. Sci. – 2017. – Vol.39. – P.381.
Cai, Y-Z Characterization and application of betalain pigments from plants of the Amaranthaceae / Y.-Z. Cai, M. Sun, H. Corke // Trends in Food Science & Technology. – 2005. – Vol.16. – Is.9. – P.370–376.
Characterization of major betalain pigments - gomphrenin, betanin and isobetanin from Basella rubra L. fruit and evaluation of efficacy as a natural colourant in product (ice cream) development / S.S. Kumar, P. Manoj, N.P. Shetty [et al.] // J Food Sci Technol. – 2015. – Vol.52. – N.8. – P.4994–5002.
Structural Identification and Bioactivities of Red-Violet Pigments Present in Basella alba Fruits / S.M. Lin, B.H. Lin, W.M. Hsieh [et al.] // J Agric Food Chem. – 2010. – Vol.58. – N.19. – P.10364–10372.
Betalains in red and yellow varieties of the Andean tuber crop ulluco (Ullucus tuberosus) / J. Svenson, B.M. Smallfield, N.I. Joyce [et al.] // J Agric Food Chem. – 2008. – Vol.56. – N17. – P.7730–7737.
Gilbert, M. A Review of Gisekia (Gisekiaceae) / M. Gilbert // Kew Bulletin., 1993. – Vol.48, No.2. – P.343–356.
Mabry, T.J. Betalains and P-type sieve-element plastids in Gisekia L. (Centrospermae) / T.J. Mabry, H.-D. Behnke, I. Eifert // Taxon. – 1976. – Vol.25. – N1. – P.112–114.
Hunziker J., Behnke H.-D., Eifert I., Mabry T.J Halophytum Ameghinoi: A Betalain-Containing and P-Type Sieve-Tube Plastid Species. Taxon. – 1974. – Vol.23. – P.537.
Mabry, T.J. Hectorella: A member of the betalain-suborder Chenopodiineae of the order Centrospermae / T.J. Mabry, P. Neuman, W.R. Philipson // Pl. Syst Evol. – 1978. – Vol. 130. – P.163–165.
Rauh, W. The morphology and systematic position of the Didiereaceae of Madagascar / W. Rauh // Bothalia: African Biodiversity & Conservation. – 1983. – Vol.14. – N(3/4). – P.839–843.
Color, betalain pattern, and antioxidant properties of cactus pear (Opuntia spp.) clones / F.C. Stintzing, K.M. Herbach, M.R. Mosshammer [et al.] //J Agric Food Chem. – 2005. – Vol.53. – N2. – P.442–451.
Stintzing, F.C. Betacyanins in fruits from red-purple pitaya, Hylocereus polyrhizus (Weber) Britton & Rose / F.C. Stintzing, A. Schieber, R. Carle // Food Chem. – 2002. – Vol.77. – Is.1. – P.101–106.
De Aguiar Lage, D. Production of betalains from callus and cell suspension cultures of Pereskia aculeata Miller, an unconventional leafy vegetable / D. De Aguiar Lage, M. da Silva Tirado, S.R. Vanicore // Plant Cell Tiss Organ Cult. – 2015. – Vol.122. – P.341–350.
Santos-Diaz, M.S. Pigment production by callus of Mammillaria candida Scheidweiler (Cactaceae) / M.S. Santos-Diaz, Y. Velasquez-Garcia, M.M. Gonzalez-Chavez // Agrociencia. – 2005. – Vol.39. – P.619–626.
Wybraniec, S. Mammillarinin: A New Malonylated Betacyanin from Fruits of Mammillaria / S. Wybraniec, B. Nowak-Wydra // J Agr food chem. – 2007. – Vol.55. – P.8138–8143.
Janick, J. Horticultural Reviews / J. Janick. – Vol.42. – 2014. – John Wiley & Sons. – 504 pp.
Socaciu, C. Food Colorants: Chemical and Functional Properties CRC Press / C. Socaciu. – 2007. – 648 pp.
Separation of betalains from berries of Phytolacca americana by ion-pair high-speed counter-current chromatography / G. Jerz, T. Skotzki, K. Fiege [et al.] // J chromatogr. A. – 2018. – Vol. 1190. – P.63–73.
Phylogeny and generic delimitation in Molluginaceae, new pigment data in Caryophyllales, and the new family Corbichoniaceae / M. Thulin,
A.J. Moore, H. El-Seedi [et al.] // Taxon. – 2016. – Vol.65. – P.775–793.
Chemical and nutritional characterization of Chenopodium quinoa Willd (quinoa) grains: A good alternative to nutritious food / E. Pereira, C. Encina-Zelada, L. Barros [et al.] // Food Chem. – 2019. – Vol.280. – P.110–114.
Thermal and pH stability of betacyanin pigment of Djulis (Chenopodium formosanum) in Taiwan and their relation to antioxidant activity / P. Tsai, C. Sheu, P. Wu, Y. Sun // Journal of agricultural and food chemistry. – 2010. – Vol.58. – N2. – P.1020–1025.
Identification of betacyanin and effects of environmental factors on its accumulation in halophyte Suaeda salsa / C.Q. Wang, J.Q. Zhao, M. Chen, B.S. Wang // Zhi wu sheng li yu fen zi sheng wu xue xue bao. – 2006. – Vol.32. – N2. – P.195–201.
Characterisation of betalain biosynthesis in Parakeelya flowers identifies the key biosynthetic gene DOD as belonging to an expanded LigB gene family that is conserved in betalain-producing species / H.H. Chung, K.E. Schwinn, H.M. Ngo [et al.] // Front Plant Sci. – 2015. – Vol.6. – P.499.
The Western Spring Beauties, Claytonia lanceolata (Montiaceae): A Review and Revised Taxonomy For California / T.R. Stoughton, D.D. Jolles, R.L. O’Quinn // Systematic Botany. – 2017. – Vol.42. – N2. – P.283–300.
Transcriptome and Metabolic Profiling Provides Insights into Betalain Biosynthesis and Evolution in Mirabilis jalapa / G. Polturak, U. Heinig, N. Grossman [et al.] // Mol Plant. – 2018. – Vol.11. – N1. – P.189–204.
Abarca-Vargas, R. Bougainvillea Genus: A Review on Phytochemistry, Pharmacology, and Toxicology / R. Abarca-Vargas, V.L. Petricevich // Evid Based Complement Alternat Med. – 2018. – Vol.24 – 9070927 eCollection, 2018.
Pigment identification, nutritional composition, bioactivity, and in vitro cancer cell cytotoxicity of Rivina humilis L. berries, potential source of betalains / M.I. Khan, P. Harsha, P. Giridhar, G.A. Ravishankar // Lwt-Food Sci. Technol. – 2012. – Vol.47. – pp. 315–323.
Characterization and Functional Identification of a Novel Plant 4,5-Extradiol Dioxygenase Involved in Betalain Pigment Biosynthesis in Portulaca grandiflora / L. Christinet, F.H. Burdet, M. Zaiko [et al.] // Plant Physiology. – 2004. – Vol.134. – N1. – P.265–274.
Trezzini, G.F. Two betalains from Portulaca grandiflora / G.F. Trezzini, J.P. Zr?d // Phytochemistry. – 1991. – Vol.30. – P.1897–1899.
Chemical Review and Evolutionary Significance of the Betalains / J.S. Clement, T.J. Mabry, H. Wyler, A.S. Dreiding // In: Behnke HD., Mabry T.J. (eds) Caryophyllale. – 1994. – Springer, Berlin, Heidelberg. – pp 247–261.
Characterisation and determination of in vitro antioxidant potential of betalains from Talinum triangulare (Jacq.) Willd / J. Swarna, T.S. Lokeswari, M. Smita, R. Ravindhran // Food Chem. – 2013. – Vol.141. – N4. – P.4382–4390.
Zryd, J.P. Betalains / J.P. Zryd, L. Christinet // In: Plant pigments and their manipulation. Eds: Davies K, Ann Plant Rev. – 2004. – Vol.14. – John Wiley & Sons. – P.203.
Davies, K. Annual Plant Reviews / K. Davies – Vol. 14. – Plant Pigments and their Manipulation, John Wiley & Sons, 2009. – 368 pp.
The Alkaloids: Chemistry and Pharmacology / A. Brossi (ed.). Vol. 39, Academic Press. – 1991. – P.53.
First Betalain-Producing Bacteria Break the Exclusive Presence of the Pigments in the Plant Kingdom / L.E. Contreras-Llano, M.A. Guerrero-Rubio, J.D. Lozada-Ram?rez [et al.] // mBio. – 2019. – Vol.10. – N2. – e00345-19.
Anthocyanins and betalains as light-harvesting pigments for dye-sensitized solar cells / G. Calogero, J.-H. Yum, A. Sinopoli [et al.] // Solar Energy. – 2012. – Vol.86. – Is. 5. – P.1563–1575.
Betanin, a Natural Food Additive: Stability, Bioavailability, Antioxidant and Preservative Ability Assessments. / D. Vieira Teixeira da Silva, D. Dos Santos Bai?o, F. de Oliveira Silva [et al.] // Molecules. – 2019. – Vol.24. – N3. – pii: E458.
Betaxanthin-Rich Extract from Cactus Pear Fruits as Yellow Water-Soluble Colorant with Potential Application in Foods. / J.A. Fern?ndez-L?pez, M.J. Roca, J.M. Angosto, J.M. Ob?n // Plant Foods Hum Nutr. – 2018. – Vol.73. – N2. – P.146–153.
Belhadj Slimen, I. Chemical and Antioxidant Properties of Betalains / I. Belhadj Slimen, T. Najar, M. Abderrabba // J. Agric Food Chem. – 2017. – Vol.65. – N4. – P.675–689.
Light quality and plant growth regulators influence pigment production in Alternanthera brasiliana calli / A. Reis, A. Kleinowski, R. Telles [et al.] // Afr. J. Biotechnol. – 2018. – Vol.17. – P.638–648.
Choo, W.S. Betalains: Application in Functional Foods / W.S. Choo // In: M?rillon JM., Ramawat K. (eds) Bioactive Molecules in Food. Reference Series in Phytochemistry. – Springer. – 2018. – P.1–28.
Study on Betalains in Celosia cristata Linn. Callus Culture and Identification of New Malonylated Amaranthins / K. Lystvan, A. Kumorkiewicz, E. Szneler, S. Wybraniec // J Agric Food Chem. – 2018. – Vol.66. – N(15). – P.3870–3879.
Production of dihydroxylated betalains and dopamine in cell suspension cultures of Celosia argentea var. plumosa / B. Guadarrama-Flores, M. Rodr?guez-Monroy, F. Cruz-Sosa [et al.] // J. Agric Food Chem. – 2015. – Vol.63. – N10. – P.2741–2749.
Development of Betalain Producing Callus Lines from Colored Quinoa Varieties (Chenopodium quinoa Willd) / P. Henarejos-Escudero, B. Guadarrama-Flores, M.A. Guerrero-Rubio [et al.] // J. Agric Food Chem. – 2018. – Vol.66. – N2. – P.467–474.
Betanin - a food colorant with biological activity / T. Esatbeyoglu, A.E. Wagner, V.B. Schini-Kerth, G. Rimbach // Mol Nutr Food Res. – 2015. – Vol.59. – N1. – P.36–47.
Betalains, the nature-inspired pigments, in health and diseases / P. Rahimi, S. Abedimanesh, S.A. Mesbah-Namin, A. Ostadrahimi // Crit Rev Food Sci Nutr. – 2018. – Vol.30. – P.1–30.
Gand?a-Herrero, F. Biological Activities of Plant Pigments Betalains / F. Gand?a-Herrero, J. Escribano, F. Garc?a-Carmona // Crit Rev Food Sci Nutr. – 2016. – Vol.56. – N6. – P.937–945.
Dictionary of Alkaloids with CD-ROM / J. Buckingham, K.H. Baggaley, A.D. Roberts, L.F. Szabo. – CRC Press. – 2010. – P.280–181.
The potential benefits of red beetroot supplementation in health and disease / T. Clifford, G. Howatson, D.J. West, E.J. Stevenson // Nutrients. – 2015. – Vol.7. – N4. – P.2801–2822.
Antioxidant Activity of Betanidin: Electrochemical Study in Aqueous Media / S. Wybraniec, P. Stalica, A. Sp?rna [et al.] // J. Agric. Food Chem. – 2011. – Vol.59. – N22. – P.12163–12170.
Granit, R. Betalains – A new class of dietary cationized antioxidants / R. Granit, S. Harel, J. Kanner // J. Agric Food Chem. – 2001. – Vol.49. – N11. – P.5178–5185.
Lugo-Radillo, A. Betanidin significantly reduces blood glucose levels in BALB/c mice fed with an atherogenic diet / A. Lugo-Radillo, I. Delgado-Enciso, E. Pena-Beltran // Nat Prod Bioprospect. – 2012. – Vol.2. – N4. – P.154–155.
Sawicki, T. The effects of boiling and fermentation on betalain profiles and antioxidant capacities of red beetroot products / T. Sawicki, W. Wiczkowski // Food Chem. – 2018. – Vol.59. – P.292–303.
Содержание и пигментный состав автотрофной и гетеротрофной ткани листьев амаранта вида A. tricolor L. / М.С. Гинс, В.Ф. Пивоваров, В.К. Гинс [и др.] // Овощи России. – 2016. – N3. – C.79–83.
Betaxanthin-Rich Extract from Cactus Pear Fruits as Yellow Water-Soluble Colorant with Potential Application in Foods / J.A. Fern?ndez-L?pez, M.J. Roca, J.M. Angosto, J.M. Ob?n // Plant Foods Hum Nutr. – 2018. – Vol.73. – N2. – P.146–153.
Choo, S.W. Antioxidant properties of two species of Hylocereus fruits / S.W. Choo, K.W. Yong // Adv. Appl. Sci. Res. – 2011. – Vol.2. – N3. – P.418–425.
Antioxidant properties, quantification and stability of betalains from pitaya (Hylocereus undatus) peel / F.R. Mello, C. De Bernardo, C.O. Dias [et al.] // Food Technol. – 2015. – Vol.45. – N2. – P.323–328.
S?enz, C. Red betalains from Opuntia spp.: Natural colorants with potential applications in foods / C. S?enz, B. Cancino, R. Paz // Isr J Plant Sci. – 2012. – Vol. 60. – Is. 3. – P.291–299.
Betanin-Enriched Red Beetroot (Beta vulgaris L.) Extract Induces Apoptosis and Autophagic Cell Death in MCF-7 Cells / L. Nowacki, P. Vigneron, L. Rotellini [et al.] //Phytother Res. – 2015. – Vol.29. – N.12. – P.1964–1973.
Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancer cell lines / G.J. Kapadia, M.A. Azuine, G.S. Rao [et al.] // Anticancer Agents Med Chem. – 2011. – Vol.11. – N3. – P.280–284.
Synergistic cytotoxicity of red beetroot (Beta vulgaris L.) extract with doxorubicin in human pancreatic, breast and prostate cancer cell lines / G.J. Kapadia, G.S. Rao, C. Ramachandran [et al.] // J. Complement Integr Med. – 2013. – Jun 26;10. pii: /j/jcim.2013.10.issue-1/jcim-2013-0007/jcim-2013-0007.xml.
Betalain and betaine composition of greenhouse- or field-produced beetroot ( Beta vulgaris L.) and inhibition of HepG2 cell proliferation / E.J. Lee, D. An, C.T. Nguyen [et al.] // J. Agric Food Chem. – 2014. – Vol.62. – N6. – P.1324–1331.
Pigment identification, nutritional composition, bioactivity, and in vitro cancer cell cytotoxicity of Rivina humilis L. berries, potential source of betalains / M.I. Khan, P.S.C. Sri Harsha, P. Giridhar, G.A. Ravishankar // LWT Food Sci Technol. – 2012. – Vol.47. – P.315–323.
Betanin a betacyanin pigment purified from fruits of Opuntia ficus-indica induces apoptosis in human chronic myeloid leukemia cell line-K562 / D. Sreekanth, M.K. Arunasree, K.R. Roy [et al.] // Phytomedicine. –2007. – Vol.14. – P.739–746.
Pro-oxidant activity of indicaxanthin from Opuntia ficus indica modulates arachidonate metabolism and prostaglandin synthesis through lipid peroxide production in LPS-stimulated RAW 264.7 macrophages / M. Allegraa, F. D’Acquistob, L. Tesorierea [et al.] // Redox Biology. – 2014. – Vol.2. – P.892–900.
Indicaxanthin from Opuntia ficus-indica Crosses the Blood–Brain Barrier and Modulates Neuronal Bioelectric Activity in Rat Hippocampus at Dietary-Consistent Amounts / M. Allegra, F. Carletti, G. Gambino [et al.] // J. Agr Food Chem. – 2015. – Vol.63. – N33. – P.7353–7360.
Indicaxanthin from cactus pear fruit exerts anti-inflammatory effects in carrageenin-induced rat pleurisy / M. Allegra, A. Ianaro, M. Tersigni [et al.] // J Nutr. – 2014. – Vol.144. – N(2). – P.185–192.
Thermoprotective properties of Opuntia ficus-indica f. inermis cladodes and mesocarps on sheep lymphocytes / I. Belhadj Slimen, H. Chabaane, M. Chniter [et al.] // J Therm Biol. – 2019. – Vol.81. – P.73–81.
Secondary metabolites of Mirabilis jalapa structurally inhibit Lactate Dehydrogenase A in silico: a potential cancer treatment / R. Kusumawati,
A.H. Nasrullah, R.N. Pesik [et al.] // International Conference on Advanced Materials for Better Future 2017 IOP Publishing IOP Conf. Series: Materials Science and Engineering 333.-2018. – 012078.
Pangestu, A. Neuroglobin activator found from Mirabilis Jalapa for stroke treatment / A. Pangestu, D. Indarto, B. Balgis // AIP Conference Proceedings. – 2018. – Vol. 2021. – 070002.
Indicaxanthin, Miraxanthin-V, and Hexahydrocurcumin as Potential Erythropoietin Agonist in Silico to Treat Anemia in Chronic Kidney Disease / Y. Suselo, K. Kamil, S. Wulandari, D. Indarto // Health Science International Conference (HSIC 2017). – 2017. – 10.2991/hsic-17.2017.62.
Miraxanthin-V, Liriodenin and Chitranone are Hepcidin Antagonist In silico for Iron Deficiency Anemia / S. Yotriana, Y. Suselo, M. Muthmaina, D. Indarto // IOP Conference Series: Materials Science and Engineering. – 2018. – 10.2991/hsic-17.2017.62.
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