САНГВИНАРИЯ КАНАДСКАЯ (SANGUINARIA CANADENSIS L.)

Публикация 2: биологическое действие, применение в традиционной медицине и современной мировой медико-фармацевтической практике

Авторы

  • Н.В. Колман Городской Университет Штата Нью Джерси (Нью-Джерси, США)
  • Татьяна Леонидовна Киселева Профессиональная ассоциация натуротерапевтов

Ключевые слова:

традиционная медицина, Sanguinaria Canadensis L., кровавый корень, сангвинарин, сангвинария, сангвинария канадская, алкалоиды, противоопухолевое действие, противовирусное действие, противомикробное действие

Аннотация

Проведено информационно-аналитическое исследование спектра биологической активности, опыта традиционного применения и современных представлений о перспективах использования сангвинарии канадской (Sanguinaria Canadensis L.) в современной медико-фармацевтической практике. Показано, что накопленный этноботанический и этнофармакологический материал обусловил значительный интерес к экспериментальному и клиническому изучению сангвинарии со стороны отдельных исследователей и целых научных коллективов.
На основании анализа опубликованных результатов исследований показано противоопухолевое, противовоспалительное, противомикробное, противовирусное, противопаразитарное, антидиабетическое действие экстрактов корневищ и отдельных алкалоидов, выделенных из этого растения. Выявлены работы, описывающие механизмы действия сангвинарина и хелеритрина на раковую клетку, а также процессы, обусловливающие противоопухолевый эффект алкалоидов сангвинарии, их влияние на деятельность желудка и кишечника, сердца и сосудов, а также на резистентность к инсулину.
Таким образом, проведенное исследование позволило установить, что корневища сангвинарии могут являться перспективным источником современных отечественных лекарственных препаратов и/или фитонутриентов для создания БАД к пище и специализированных пищевых продуктов.

Биография автора

Татьяна Леонидовна Киселева, Профессиональная ассоциация натуротерапевтов

Доктор фармацевтических наук, профессор

Библиографические ссылки

Киселева, Т.Л. Сангвинария канадская (Sanguinaria canadensis L.). Публикация 1: ботаническая характеристика, синонимика, химический состав, использование в стоматологии, гомеопатии и ветеринарии, опыт пищевого применения / Т.Л. Киселева, Н.В. Колман, М.А. Киселева // Традиционная медицина. – 2019. – № 4 (59).

Abu-Ghalyun, Y. Effects of allocryptopine, an alkaloid isolated from glaucium arabicum on rat isolated ileum and urinary bladder / Y. Abu-Ghalyun, A. Masalmeh,

S. Al-Khalil // Gen. Pharmacol. Vasc. Syst. – 1997; 29: 621–623.

Sanguinarine causes cell cycle blockade and apoptosis of human prostate carcinoma cells via modulation of cyclin kinase inhibitor-cyclin-cyclin-dependent kinase machinery / V.M. Adhami, M.H. Aziz, S.R. Reagan-Shaw [et al.] // Mol. Cancer Ther. – 2004; 3: 933–940.

Differential antiproliferative and apoptotic response of sanguinarine for cancer cells versus normal cells / N. Ahmad, S. Gupta, M.M. Husain [et al.] // Clin. Cancer Res. – 2000; 6: 1524–1528.

Sanguinarine induces apoptosis of human pancreatic carcinoma AsPC-1 and BxPC-3 cells via modulations in Bcl-2 family proteins / H. Ahsan, S. Reagan-Shaw, J. Breur, N. Ahmad // Cancer Lett. – 2007; 249: 198–208.

Protective effect of sanguinarine on ultraviolet B-mediated damages in SKH-1 hairless mouse skin: Implications for prevention of skin cancer / H. Ahsan, S. Reagan-Shaw, D.M. Eggert [et al.] // Photochem. Photobiol. – 2007; 83: 986–993.

Akbarov, Z.S. Comparative study of the anti-arrhythmic action of the alkaloid a-allocryptopine with quinidine / Z.S. Akbarov, K. Aliev, M.B. Sultanov // Dokl. Akad. Nauk Uzb. – 1972; 29: 38.

Albelda, S.M. Adhesion molecules and inflammatory injury / S.M. Albelda, C.W. Smith, P. Ward // FASEB J. – 1994; 8: 504–512.

Allen, J.A. Remarks on the treatment of tracheitis, or croup / J.A. Allen // Boston Med. Surg. J. – 1845; 33: 389–392. doi: 10.1056/NEJM184512170332001 [Электронный ресурс]. – Доступ: https://www.nejm.org/doi/full/10.1056/NEJM184512170332001 (по состоянию на 12.11.2019)

Ansari, K.M. Potentiation of tumour promotion by topical application of argemone oil/isolated sanguinarine alkaloid in a model of mouse skin carcinogenesis / K.M. Ansari, M. Das // Chem. Biol. Interact. – 2010; 188: 591–597.

Austin, S. Long term follow-up of cancer patients using contreras, hoxsey and gerson therapies / S. Austin, E. Baumgartner, S. DeKadt // J. Naturop. Med. – 1995; 5: 74–76.

Protopine reduces the inflammatory activity of lipopolysaccharide-stimulated murine macrophages / D.S. Bae, Y.H. Kim, C.-H. Pan [et al.] // BMB Rep. – 2012; 45: 108.

Ligand binding to tandem g quadruplexes from human telomeric DNA / L.P. Bai, M. Hagihara, Z.H. Jiang, K. Nakatani // ChemBioChem. 2008; 9:2583–2587. doi: 10.1002/cbic.200800256.

DNA-binding affinities and sequence selectivity of quaternary benzophenanthridine alkaloids sanguinarine, chelerythrine, and nitidine / L.P. Bai, Z.Z. Zhao, Z. Cai, Z.H. Jiang // Bioorg. Med. Chem. – 2006; 14: 5439–5445.

Sequence-selective, pH-dependent binding to DNA of benzophenanthridine alkaloids / N.P. Bajaj, M.J. McLean, M.J. Waring, E. Smekal // J. Mol. Recognit. – 1990; 3: 48–54.

Inhibition of mouse liver respiration by Chelidonium majusisoquinoline alkaloids / Barreto M.C., Pinto R.E., Arrabaca J.D., Pavao M.L. // Toxicol. Lett. – 2003; 146: 37–47.

Bartholow, R. A Practical Treatise on Materia Medica and Therapeutics / R. Bartholow. – New York, NY, USA: D. Appleton, 1888. – Р. 359–361.

Barton, W.P.C. Vegetable Materia Medica of the United States, or, Medical Botany: Containing a Botanical, General, and Medical History, of Medicinal Plants Indigenous to the United States: Illustrated by Colored Engravings, Made after Original Drawings from Nature, Done by the Author / W.P.C. Barton. – Philadelphia, PA, USA: M. Carey & Son, 1817. – Р. 30–42.

Beach, W. The American Practice of Medicine / W. Beach. Volume 2. – New York, NY, USA: Betts & Anstice, 1833. – Р. 259–261.

Bennett, B.C. Geographic variation in alkaloid content of Sanguinaria Canadensis (Papaveraceae) / B.C. Bennett, C.R. Bell, R.T. Boulware // Biology. – 1990; 92: 57–69.

Bent, S. Herbal medicine in the united states: Review of efficacy, safety, and regulation / S. Bent // J. Gen. Intern. Med. – 2008; 23: 854–859.

Structure-activity relationship studies of phenanthridine-based Bcl-Xl inhibitors / P.H. Bernardo, K.F. Wan, T. Sivaraman [et al.] // J. Med. Chem. – 2008; 51: 6699–6710.

Eds., Hager’s Handbuch der Pharmazeutischen Praxis / W. Blaschek [et al.] Auflage Band 2 (A-K). – Berlin: Springer-Verlag, 1998.

Bloodroot (Sanguinaria canadensis) // United Plant Savers [Электронный ресурс]. – Доступ: https://unitedplantsavers.org/bloodroot-sanguinaria-canadensis/ (по состоянию на 11.11.2019).

Board, S. Botanical medicines – The need for new regulations / S. Board // N. Engl. J. Med. – 2002; 347: 2073–2076.

A genetic explanation of slaughter’s concept of field cancerization evidence and clinical implications / B.J. Braakhuis, M.P. Tabor, J.A. Kummer [et al.] // Cancer Res. – 2003; 63: 1727–1730.

Byrn, S.R. Analysis of binding of daunorubicin and doxorubicin to DNA using computerized curve-fitting procedures / S.R. Byrn, G.D. Dolch // J. Pharm. Sci. – 1978; 67: 688–693.

Inhibitory activity on binding of specific ligands to the human angiotensin II AT1 and endothelin 1 ETA receptors: Bioactive benzo[c]phenanthridine alkaloids from the root of Bocconia frutescens / C. Caballero-George, P.M. Vanderheyden, S. Apers [et al.] // Planta Med. – 2002; 68: 770–775.

Biological screening of selected medicinal panamanian plants by radioligand-binding techniques / C. Caballero-George, P. Vanderheyden, P. Solis [et al.] // Phytomedicine. – 2001; 8: 59–70.

In vitro effect of sanguinarine alkaloid on binding of [3H] candesartan to the human angiotensin AT1 receptor / C. Caballero-George, P.M.L. Vanderheyden, P.N. Solis [et al.] // Eur. J. Pharmacol. – 2003; 458: 257–262.

Cansema & Escharotics FAQ 200 Constituents; FAQ 206 What are the Side Effects; FAQ 215 Can it Be Used to Treat Melanoma; FAQ 222 Success Rate with Skin Cancer. – [Электронный ресурс]. – Доступно: http://www.altcancer.com/faqcan.htm (по состоянию на 15.07. 2016 г.).

Chamberlain, A.F. Algonkian words in american english: A study in the contact of the white man and the Indian / A.F. Chamberlain // J. Am. Folk. – 1902; 15: 240–267.

Identification of Chelerythrine as an inhibitor of BclXL function / S.-L. Chan, M.C. Lee, K.O. Tan [et al.] // J. Biol. Chem. – 2003; 278: 20453–20456.

Chandler, R.F. Vindication of maritime Indian herbal remedies / R.F. Chandler // J. Ethnopharmacol. – 1983; 9: 323–327.

Sanguinarine (pseudochelerythrine) is a potent inhibitor of NF-?B activation, I?? phosphorylation, and degradation / M.M. Chaturvedi, A. Kumar, B.G. Darnay [et al.] // J. Biol. Chem. – 1997; 272: 30129–30134.

Cheng, T.J. Identification of sanguinarine as a novel HIV protease inhibitor from high-throughput screening of 2000 drugs and natural products with a cell-based assay / T.J. Cheng, D.S. Goodsell, C.C. Kan // Lett. Drug Des. Discov. – 2005; 2: 364–371.

In vitro and in vivo activity of protein kinase C inhibitor chelerythrine chloride induces tumor cell toxicity and growth delay in vivo / S.J. Chmura, M.E. Dolan, A. Cha [et al.] // Clin. Cancer Res. – 2000; 6: 737–742.

Chowdhury, S.R. Binding of the anticancer alkaloid sanguinarine to double stranded rnas: Insights into the structural and energetics aspects / S.R. Chowdhury, M.M. Islam, G.S. Kumar // Mol. Biosyst. – 2010; 6: 1265–1276.

Cienki, J.J. An internet misadventure: Bloodroot salve toxicity / J.J. Cienki, L. Zaret // J. Altern. Complement. Med. – 2010; 16: 1125–1127.

Thiol-mediated apoptosis in prostate carcinoma cells / R.N. Coffey, R.W.G. Watson, N.J. Hegarty [et al.] // Cancer. – 2000; 88: 2092–2104.

Combined DNA, toxicological and heavy metal analyses provides an auditing toolkit to improve pharmacovigilance of traditional Chinese medicine (TCM) / M.L. Coghlan, G. Maker, E. Crighton [et al.] // Sci. Rep. – 2015; 5: 17475.

Cook, W. The Physiomedical Dispensatory / W. Cook. – USA: Wm. H. Cook; Cincinnati, OH, 1869. – Р. 466–467.

Sanguinaria canadensis: Traditional Medicine, Phytochemical Composition, Biological Activities and Current Uses / A. Croaker, G.J. King, J.H. Pyne [et al.] // Int. J. Mol. Sci. – 2016 Sep; 17(9): 1414. – Published online 2016 Aug 27.

Binding properties of human telomeric quadruplex multimers: A new route for drug design / A. Cummaro, I. Fotticchia, M. Franceschin [et al.] // Biochimie. – 2011; 93: 1392–1400.

Leukoplakia of the maxillary vestibule – An association with viadent? / D.D. Damm, A. Curran, D.K. White, J.E. Drummond // Oral Surg. Oral Med. 1999; 87: 61–66. doi: 10.1016/S1079-2104(99)70296-9.

Das, S. Conversions of the left-handed form and the protonated form of DNA back to the bound right-handed form by sanguinarine and ethidium: A comparative study / S. Das, G.S. Kumar, M. Maiti // Biophys. Chem. – 1999; 76: 199–218.

Spectroscopic and thermodynamic studies on the binding of sanguinarine and berberine to triple and double helical DNA and RNA structures / S. Das, G.S. Kumar, A. Ray, M. Maiti // J. Biomol. Struct. Dyn. – 2003; 20: 703–713.

Debiton, E. Sanguinarine-induced apoptosis is associated with an early and severe cellular glutathione depletion / E. Debiton, J.C. Madelmont, J. Legault, C. Barthomeuf // Cancer Chemother. Pharmacol. – 2003; 51: 474–482.

Densmore, F. Uses of plants by the Chippewa Indians / F. Densmore // Bur. Am. Ethnol. Bull. – 1928; 44: 275–397.

Desaulniers, V. Bloodroot: An ancient remedy that can heal cancer? / V. Desaulniers // TTAC (Опубликовано 21.07.2016 г.) [Электронный ресурс]. – Доступ: https://thetruthaboutcancer.com/bloodroot/ (по состоянию на 11.1.2019)

Antiproliferative and antiangiogenic effects of the benzophenanthridine alkaloid sanguinarine in melanoma / I. De Stefano, G. Raspaglio, G.F. Zannoni [et al.] // Biochem. Pharmacol. – 2009; 78: 1374–1381.

Downey, W. An Investigation of the Properties of the Sanguinaria canadensis or Puccoon / W. Downey. – Philadelphia, PA, USA: Eaken & Mecum., 1803. – Р. 23–25.

Duke, J.A. Handbook of Medicinal Herbs / J.A. Duke. – CRC Press, Boca Raton, FL, 1985.

Duke, J.A. Handbook of Medicinal Herbs / J.A. Duke; 2-nd eddition. – Boca Raton-London-New York-Washington: CRC Press, 2002. – 896 с.

Dzink, J.L. Comparative in vitro activity of sanguinarine against oral microbial isolates / J.L. Dzink, S.S. Socransky // Antimicrob. Agents Chemother. – 1985; 27: 663–665.

Earth Circle Creation [Электрогнный ресурс]. – Доступно: (http://shop.earthcirclecreations.com/product_info.php?cPath=61&products_id=26315 по состоянию на 15. 07.2016).

Eastman, K.L. A review of topical corrosive black salve / K.L. Eastman, L.V. McFarland, G.J. Raugi // J. Altern. Complement. Med. – 2014; 20: 284–289.

Eberle, J. A Treatise of the Materia Medica and Therapeutics / J. Eberle. Volume 2. – Philadelphia, PA, USA: Grigg & Elliot, 1834. – Р. 73–76.

Ellingwood, F. American Materia Medica, Therapeutics and Pharmacognosy: Developing the Latest Acquired Knowledge of Drugs, and Especially of the Direct Action of Single Drugs upon Exact Conditions of Disease, With Especial Reference to the Therapeutics of the Plant Drugs of the Americas / F. Ellingwood, J.U. Lloyd. – Evanston, IL, USA: Ellingwoods’ Therapeutist, 1915. – Р. 386–387.

Engel, R. Ueber Das Protopin. Naunyn Schmiedebergs / R. Engel // Arch. Exp. Pathol. Pharmakol. – 1890; 27: 419–431.

Erichsen-Brown, C. Medicinal and other Uses of North American Plants: A Historical Survey with Special Reference to the Eastern Indian Tribes / C. Erichsen-Brown. – North Chelmsford, MA, USA: Courier Corporation, 2013.

Eun, J.P. Suppression of angiogenesis by the plant alkaloid, sanguinarine / J.P. Eun, G.Y. Koh // Biochem. Biophys. Res. Commun. – 2004; 317: 618–624.

Farrow, R.T. Odyssey of an American cancer specialist of a hundred years ago / R.T. Farrow // Bull. Hist. Med. – 1949; 23: 236–262.

Father‘s Nature‘s Farmacy (online database). [Электронный реурс]. – Доступно: http://www.ars-grin.gov/duke/ (по состоянию на 15.07. 2016).

Fell, J.W. A Treatise on Cancer, and Its Treatment / J.W. Fell. – London, UK: John Churchill, 1857. – Р. 59–63.

Felter, H.W. King’s American Dispensatory / H.W. Felter, J.U. Lloyd. – Cincinnatti, OH, USA: Ohio Valley Co., 1898. – Sanguinaria(u.S.P.) – Sanguinaria. – Р.1708–1714.

Felter, H.W. King’s American Dispensatory / H.W. Felter, J.U. Lloyd. 2 vols., 18th ed., 3rd revision, 1898; 2 vols. reprinted Eclectic Medical Publications, Portland, OR, 1983.

PDR for Herbal Medicine / T. Fleming [et al.]. 1st ed., Medical Economics Co., Montvale, NJ, 1998.

Antitumor effects of the benzophenanthridine alkaloid sanguinarine: Evidence and perspectives / R. Gaziano, G. Moroni, C. Bu? C. [et al.] // World J. Gastrointest. Oncol. – 2016; 8: 30–39. doi: 10.4251/wjgo.v8.i1.30.

Gesler, W.M. Therapeutic landscapes: Medical issues in light of the new cultural geography / W.M. Gesler // Soc. Sci. Med. – 1992; 34: 735–746.

Plant alkaloid chelerythrine induced aggregation of human telomere sequence – A unique mode of association between a small molecule and a quadruplex / S. Ghosh, J. Jana, R.K. Kar [et al.] // Biochemistry. – 2015; 54: 974–986.

Gibb, G.D. The Sanguinaria canadensis: Its natural history, properties, and medical uses / G.D. Gibb // BMJ. – 1860; 4: 104–107.

Inhibition of the B to Z transition in poly (dGdC). Cntdot. Poly (dGdC) by covalent attachment of ethidium: Kinetic studies / P.L. Gilbert, D.E. Graves, M. Britt, J.B. Chaires // Biochemistry. – 1991; 30: 10931–10937.

Gilmore, M.R. Uses of Plants by the Indians of the Missouri River Region. Lincoln / M.R. Gilmore. – NE, USA: University of Nebraska Press, 1991. – Р. 44–45.

Giri, P. Molecular aspects of small molecules-poly(A) interaction: An approach to RNA based drug design / P. Giri, G.S. Kumar // Curr. Med. Chem. – 2009; 16: 965–987.

Goto, K. Studies on the Alkaloids of Macleya cordata R. / K. Goto, R. Oda // J. Pharm. Soc. Jpn. – 1949; 69: 307.

Graham, D.Y. Helicobacter pylori treatment in the era of increasing antibiotic resistance / D.Y. Graham, L. Fischbach // Gut. – 2010; 59:1143–1153. doi: 10.1136/gut.2009.192757.

Grieve, M. A Modern Herbal the Medicinal Culinary Cosmetic and Economic Properties Cultivation and Folk-Lore of Herbs, Grases Fungi, Shrubs & Trees with All Their Modern Uses / M. Grieve, C.F. Leyel. – New York, NY, USA: Harcourt, Brace & Co., 1931.

Neutrophil apoptosis and clearance from neonatal lungs / J. Grigg, M. Silverman, J. Savill [et al.] // Lancet. – 1991; 338: 720–722.

PDR for Herbal Medicines / J. Gruenwald [et al.] 2nd ed. – Medical Economics Co., Montvale, NJ, 2000.

Sanguinarine-induced apoptosis in lung adenocarcinoma cells is dependent on reactive oxygen species production and endoplasmic reticulum stress / S. Gu, X.-C. Yang, X.-Y. Xiang [et al.] // Oncol. Rep. – 2015; 34: 913–919.

Hall, A. The role of glutathione in the regulation of apoptosis / A. Hall // Eur. J. Clin. Investig. – 1999; 29: 238–245.

Benzo[c]phenanthridine alkaloids exhibit strong anti-proliferative activity in malignant melanoma cells regardless of their p53 status / J. Hammerova, S. Uldrijan, E. Taborska, I. Slaninova // J. Dermatol. Sci. – 2011; 62: 22–35.

Necroptosis modulated by autophagy is a predominant form of melanoma cell death induced by sanguilutine / J. Hammerova, S. Uldrijan, E. Taborska [et al.] / Biol. Chem. – 2012; 393: 647–658.

Hamoud, R. Synergistic antimicrobial activity of combinations of sanguinarine and EDTA with vancomycin against multidrug resistant bacteria / R. Hamoud, J. Reichling, M. Wink // Drug Metab. Lett. – 2014; 8: 119–128.

Induction of apoptosis by sanguinarine in C6 rat glioblastoma cells is associated with the modulation of the Bcl-2 family and activation of caspases through downregulation of extracellular signal-regulated kinase and Akt / M.H. Han, S.O. Kim, G.Y. Kim [et al.] // Anticancer Drugs. – 2007. – 18. – Р. 913–921.

Hannah, J.J. Long-term clinical evaluation of toothpaste and oral rinse containing sanguinaria extract in controlling plaque, gingival inflammation, and sulcular bleeding during orthodontic treatment / J.J. Hannah, J.D. Johnson, M.M. Kuftinec // Am. J. Orthod. Dentofac. Orthop. – 1989; 96: 199–207.

Prevalence of complementary and alternative medicine (CAM) use by the general population: A systematic review and update / P. Harris, K. Cooper, C. Relton, K. Thomas // Int. J. Clin. Pract. – 2012; 66: 924–939.

Hartwell, J.L. Plants Used Against Cancer: A Survey / J.L. Hartwell. Quarterman Publications, Inc., Lawrence, MA, 1982 (Reprinted from 1 different issues of Lloydia).

Haslett, C. Resolution of acute inflammation and the role of apoptosis in the tissue fate of granulocytes / C. Haslett // Clin. Sci. – 1992; 83: 639–648.

He, K. Protopine inhibits heterotypic celladhesion in MDA-MB-231 cells through down-regulation of multi-adhesive factors / K. He, J.-L. Gao // Afr. J. Tradit. Complement. Altern. Med. – 2014; 11: 415–424.

Herrick, J.W. Iroquois Medical Botany / J.W. Herrick, D.R. Snow. – Syracuse, NY, USA: Syracuse University Press, 1995. – Р.127–128.

Holy, J. Disruption of nucleocytoplasmic trafficking of cyclin D1 and topoisomerase II by sanguinarine / J. Holy, G. Lamont, E. Perkins // BMC Cell Biol. – 2006; 7: 13.

Hopkins, A.L. Network pharmacology: The next paradigm in drug discovery / A.L. Hopkins // Nat. Chem. Biol. – 2008; 4: 682–690.

Hopkins, A.L. Can we rationally design promiscuous drugs? / A.L. Hopkins, J.S. Mason, J.P. Overington // Curr. Opin. Struct. Biol. – 2006; 16: 127–136.

Hoxsey, H.M. You Don’t Have to Die / H.M. Hoxsey. – New York, NY, USA: Milestone Books, 1956.

Hunter, J.D. Manners and Customs of several Indian Tribes Located West of the Mississippi: Including Some Account of the Soil, Climate, and Vegetable Productions, and the Indian Materia Medica: To Which Is Prefixed the History of the Author’s Life during a Residence of Several Years among Them / J.D. Hunter. – Minneapolis, PA, USA: Ross & Haines, 1823. – 384 p.

Up-regulation of death receptor 5 and bax translocation is necessary to induce apoptosis by sanguinarine in primary effusion lymphoma / A.R. Hussain, N.A. Al-Jomah, N.A. Sirajx [et al.] // Blood. – 2006; 108: 234B.

P53-induced up-regulation of MnSOD and GPx but not catalase increases oxidative stress and apoptosis / S.P. Hussain, P. Amstad, P. He [et al.] // Cancer Res. – 2004; 64: 2350–2356.

Resistance to praziquantel: Direct evidence from schistosoma mansoni isolated from Egyptian villagers / Ismail M., Botros S., Metwally A. [et al.] // Am. J. Trop. Med. Hyg. – 1999; 60: 932–935.

Jellinek, N. Escharotic and other botanical agents for the treatment of skin cancer: A review / N. Jellinek, M.E. Maloney // J. Am. Acad. Dermatol. – 2005; 53: 487–495.

Antiplatelet effect of sanguinarine is correlated to calcium mobilization, thromboxane and camp production / J.H. Jeng, H.L. Wu, B.R. Lin [et al.] // Atherosclerosis. – 2007; 191: 250–258.

The interaction of telomeric DNA and c-myc22 G-quadruplex with 11 natural alkaloids / X. Ji, H. Sun, H. Zhou [et al.] // Nucleic Acid Ther. – 2012; 22: 127–136.

Jones, R.R. The effect of PH on sanguinarine iminium ion form / R.R. Jones, R.J. Harkrader, G.L. Southard // J. Nat. Prod. – 1986; 49: 1109–1111.

Journal of the American Medical Association Bureau of investigation, comment on court opinion that internal cancer can be cured with medicine // JAMA. – 1951; 145: 252–253.

Kaewviyudth, S. Five new species of Dactylogyrus (Monogenea) from cyprimd fishes in Thailand / S. Kaewviyudth, S. Chinabut // Asian Fish. Sci. – 1999; 12: 391–399.

Sanguinarine activates polycyclic aromatic hydrocarbon associated metabolic pathways in human oral keratinocytes and tissues / J.M. Karp, K.A. Rodrigo, P. Pei [et al.] // Toxicol. Lett. – 2005; 158: 50–60.

Keith, C.T. Multicomponent therapeutics for networked systems / C.T. Keith, A.A. Borisy, B.R. Stockwell // Nat. Rev. Drug Discov. – 2005; 4: 71–78.

Kerbel, R.S. Tumor angiogenesis / R.S. Kerbel // N. Engl. J. Med. – 2008; 358: 2039–2049.

Kerbel, R. Clinical translation of angiogenesis inhibitors / R. Kerbel, J. Folkman // Nat. Rev. Cancer. – 2002; 2: 727–739.

Protopine from corydalis ternata has anticholinesterase and antiamnesic activities / S.R. Kim, S.Y. Hwang, Y.P. Jang [et al.] // Planta Med. – 1999; 65: 218–221.

Acetylcholinesterase inhibitors from the aerial parts of Corydalis speciosa / D.K. Kim, K.T. Lee, N.-I. Baek [et al.] // Arch. Pharm. Res. – 2004; 27: 1127–1131.

Kimyai-Asadi, A. Accuracy of serial transverse cross-sections in detecting residual basal cell carcinoma at the surgical margins of an elliptical excision specimen / A. Kimyai-Asadi, L.H. Goldberg, M.H. Jih // J. Am. Acad. Dermatol. – 2005; 53: 468–473.

Kinniburgh, A.J. A cis-acting transcription element of the c-myc gene can assume an H-DNA conformation / A.J. Kinniburgh // Nucleic Acids Res. – 1989; 17: 7771–7778.

Sanguinarine and chelerythrine: assessment of safety on pigs in ninety days feeding experiment / P. Kosina, D. Walterov?, J. Ulrichov? // Food Chem Toxicol. – 2004 Jan; 42(1): 85-91.

Krochmal, A. Medicinal plants and Appalachia / A. Krochmal // Econ. Bot. – 1968; 22: 332–337. doi: 10.1007/BF02908128.

Krstin, S. Combinations of alkaloids affecting different molecular targets with the saponin digitonin can synergistically enhance trypanocidal activity against Trypanosoma brucei / S. Krstin, H.S. Peixoto, M. Wink // Antimicrob. Agents Chemother. – 2015; 59: 7011–7017.

Kulp, M. Capillary electrophoretic study of the synergistic biological effects of alkaloids from Chelidonium majus l. In normal and cancer cells / M. Kulp, O. Bragina // Anal. Bioanal. Chem. – 2013; 405: 3391–3397.

The binding of analogues of coralyne and related heterocyclics to DNA triplexes. Biochem / L.J. Latimer, N. Payton, G. Forsyth, J.S. Lee // Cell Biol. – 1995; 73: 11–18.

Laub, D.R. Death from metastatic basal cell carcinoma: Herbal remedy or just unlucky? / D.R. Laub // J. Plast. Reconstr. Aesth. Surg. – 2008; 61: 846–848.

Regulation of glutamate level in rat brain through activation of glutamate dehydrogenase by Corydalis ternate / K.H. Lee, J. Huh, M. Choi [et al.] // Exp. Mol. Med. – 2005; 37: 371–377.

Leonard, J. On the use of Sanguinaria / J. Leonard // Boston Med. Surg. J. – 1845; 32: 457–459.

Leopold, D. A history of rhinology in North America / D. Leopold // Otolaryngol. Head Neck Surg. – 1996; 115: 283–297.

Effect of ?-allocryptopine on transient outward potassium current in rabbit ventricular myocytes / Y. Li, S. Wang, Y. Liu // Cardiology. – 2008; 111:2 29–236.

Effects of protopine on intracellular calcium and the PKC activity of rat aorta smooth muscle / B. Li, Q. Wu, J.-S. Shi [et al.] // Sheng Li Xue Bao. – 2005; 57: 240–246.

List, P.H. Hager’s Handbuch der Pharmazeutischen Praxis / P.H. List, L. Hohammer. Vols. 2–6. – 1969–1979. – Berlin: Springer-Verlag.

Lopus, M. The benzophenanthridine alkaloid sanguinarine perturbs microtubule assembly dynamics through tubulin binding. A possible mechanism for its antiproliferative activity / M. Lopus, D. Panda // FEBS J. – 2006; 273: 2139–2150.

Mackentosh, J. Receipts for the Cure of Most Diseases to the Human Family / J. Mackentosh, S. Holderwell // New York, NY, USA: U.S. National Library of Medicine, 1827. – Р. 9.

Mackraj, I. Sanguinarine / I. Mackraj, T. Govender, P. Gathiram // Cardiovasc. Ther. – 2008; 26: 75–83.

Madaus, G. Lehrbuch der Biologischen Hilfmittel / G. Madaus. Vol. 1–3, Georg Olms Verlag, Hildescheim, 1976, reprint of 1938 Madaus.

In vitro susceptibility of Helicobacter pylori to isoquinoline alkaloids from Sanguinaria Canadensis and Hydrastis Canadensis / G.B. Mahady, S.L. Pendland, A. Stoia, L.R. Chadwick // Phytother. Res. – 2003; 17: 217–221.

Influence of DNA structures on the conversion of sanguinarine alkanolamine form to iminium form / M. Maiti, S. Das, A. Sen [et al.] // J. Biomol. Struct. Dyn. – 2002; 20: 455–464.

Maiti, M. The effect of PH on the absorption and fluorescence-spectra of sanguinarine / M. Maiti, R. Nandi, K. Chaudhuri // Photochem. Photobiol. – 1983; 38: 245–249.

Malhotra, J.D. The Endoplasmic Reticulum and the Unfolded Protein Response / J.D. Malhotra, R.J. Kaufman // Semin. Cell Dev. Biol. – 2007; 18: 716–731.

Malhotra, J.D. Endoplasmic reticulum stress and oxidative stress: A vicious cycle or a double-edged sword? /

J.D. Malhotra, R.J. Kaufman // Antioxid. Redox Signal. – 2007; 9: 2277–2294.

Malhotra, J.D. Er stress and its functional link to mitochondria: Role in cell survival and death / J.D. Malhotra, R.J. Kaufman // Cold Spring Harb. Perspect. Biol. – 2011; 3: a004424.

Malikova, J. Effects of sanguinarine and chelerythrine on the cell cycle and apoptosis / J. Malikova, A. Zdarilova, A. Hlobilkova // Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czechoslov. – 2006; 150: 5–12.

The effect of chelerythrine on cell growth, apoptosis, and cell cycle in human normal and cancer cells in comparison with sanguinarine / J. Malikova, A. Zdarilova, A. Hlobilkova, J. Ulrichova // Cell Biol. Toxicol. – 2006; 22: 439–453.

Matkar, S.S. Production of hydrogen peroxide and redox cycling can explain how sanguinarine and chelerythrine induce rapid apoptosis / S.S. Matkar, L.A. Wrischnik, U. Hellmann-Blumberg // Arch. Biochem. Biophys. – 2008; 477: 43–52.

McDaniel, S. Consequences of using escharotic agents as primary treatment for nonmelanoma skin cancer / S. McDaniel, G.D. Goldman // Arch. Dermatol. – 2002; 138: 1593–1596.

American Herbal Products Association‘s Botanical Safety Handbook / McGuffln, M. [et al.], Eds. CRC Press, Boca Raton, FL, 1997.

Mechling, W.H. The malecite Indians, with notes on the Micmacs (concluded) / W.H. Mechling // Anthropologica. – 1959; 8: 161–274.

Medvetz, D. Therapeutic targeting of cellular metabolism in cells with hyperactive mTORC1: A paradigm shift / D. Medvetz, C. Priolo, E.P. Henske // Mol. Cancer Res. – 2015; 13:3–8.

Antifungal activity of the benzo[c]phenanthridine alkaloids from Chelidonium majus Linn against resistant clinical yeast isolates / F. Meng, G. Zuo, X. Hao [et al] // J. Ethnopharmacol. – 2009; 125: 494–496.

Solution chemistry and DNA binding properties of men 10755, a novel disaccharide analogue of doxorubicin / L. Messori, C. Temperini, F. Piccioli [et al.] // Bioorg. Med. Chem. – 2001; 9: 1815–1825.

Structural modification of sanguinarine and chelerythrine and their antibacterial activity / F. Miao, X.J. Yang, L. Zhou [et al.] // Nat. Prod. Res. – 2011; 25: 863–875.

Middlesex Hospital. Report of the Surgical Staff of the Middlesex Hospital to the Weekly Board of Governors upon the Treatment of Cancerous Diseases in the Hospital on the Plan Introduced by dr. Fell. London, UK: John Churchill., 1857.

Moerman, D.E. Medicinal plants of native America / D.E. Moerman // University of Michigan Museum of Antropology. – Technical report. – 1986. – № 581.634 M6.

Moerman, D.E. Native American Ethnobotany / D.E. Moerman. – Timber Press, Portland, OR, 1998.

Mohs, F.E. Chemosurgery: A microscopically controlled method of cancer excision / F.E. Mohs // Arch. Surg. – 1941; 42: 279–295.

Mohs, F.E. Chemosurgery for skin cancer: Fixed tissue and fresh tissue techniques / F.E. Mohs // Arch. Dermatol. – 1976; 112: 211–215.

Mohs F.E. Chemosurgery: Microscopically controlled surgery for skin cancer – Past, present and future / F.E. Mohs // J. Dermatol. Surg. Oncol. – 1978; 4: 41–54.

Mohs, F. Pre-excisional fixation of tissues in the treatment of cancer in rats / F. Mohs, M. Guyer // Cancer Res. – 1941; 1: 49–51.

Intercellular adhesion molecule-1 as a drug target in asthma and rhinitis / S. Mukhopadhyay, P. Malik, S.K. Arora, T.K. Mukherjee // Respirology. – 2014; 19: 508–513.

Triplex DNA-binding proteins are associated with clinical outcomes revealed by proteomic measurements in patients with colorectal cancer / L.D. Nelson, C. Bender, H. Mannsperger [et al.] // Mol. Cancer. – 2012; 11: 38.

Newall, C.A. Herbal Medicine – A Guide for Health-Care Professionals / C.A. Newall, L.A. Anderson, J.D. Phillipson. – London: The Pharmaceutical Press, 1996.

Newmark, T.M. Herbal Cox-2 Inhibition - Nature‘s Challenge to Arthritis, Cancer and Alzheimer‘s Disease / T.M. Newmark, P. Schulick. – Hohm Press, Prescott, AZ, 1996.

The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria Canadensis / S.M. Newton, C. Lau, S.S. Gurcha [et al.] // J. Ethnopharmacol. – 2002; 79: 57–67.

Nitiss, J.L. Targeting DNA topoisomerase ii in cancer chemotherapy / J.L. Nitiss // Nat. Rev. Cancer. – 2009; 9: 338–350.

Effects of chelerythrine, a specific inhibitor of cyclooxygenase-2, on acute inflammation in mice / X.-F. Niu, P. Zhou, W.-F. Li, H.-B. Xu // Fitoterapia. – 2011; 82: 620–625.

The mechanism of action of sanguinarine against methicillin-resistant staphylococcus aureus / B.W. Obiang-Obounou, O.H. Kang, J.G. Choi [et al.] // J. Toxicol. Sci. – 2011; 36: 277–283.

Ong, N.C. Use of unlicensed black salve for cutaneous malignancy / N.C. Ong, E. Sham, B.M. Adams // Med. J. Aust. – 2014; 200: 314.

Orhan, I. Antiviral and Antimicrobial Evaluation of Some Heterocyclic Compounds from Turkish Plants / I. Orhan, B. ?zcelik, B. ?ener. Volume II. – Berlin, Germany: Springer. 2007. – Р. 303–323.

Self-treatment of a basal cell carcinoma with «black and yellow salve» / Osswald S.S., Elston D.M., Farley M.F. [et al.] // J. Am. Acad. Dermatol. – 2005; 53: 509–511.

PDR for Herbal Medicines (Physician's Desk Reference for Herbal Medicines). – Ed. 45, 1991.

PDR for Herbal Medicines (Physician's Desk Reference for Herbal Medicines); 4th Edition // by Thomson Healthcare (Author); published by Thomson Reuters, 2007. – 990 р.

Peirce, A. The APhA Practical Guide to Natural Medicines / A. Peirce. – New York: Stonesong Press Book, Wm. Morrow & Co., Inc., 1999.

Evidence for a triplex DNA conformation at the Bcl-2 major breakpoint region of the t(14; 18) translocation / S.C. Raghavan, P. Chastain, J.S. Lee [et al.] // J. Biol. Chem. – 2005; – 280: – 22749–22760.

Reagan-Shaw, S. Enhancement of UVB radiation-mediated apoptosis by sanguinarine in hacat human immortalized keratinocytes / S. Reagan-Shaw, J. Breur, N. Ahmad // Mol. Cancer Ther. – 2006; 5: 418–429.

Reference to the Eastern Indian Tribes, Dover Publications, Inc., New York, 1989.

Rich, A. Speculation on the biological roles of left-handed Z-DNAa / A. Rich //Ann. N. Y. Acad. Sci. – 1994; 726: 1–17.

Assessment of outcomes at alternative medicine cancer clinics: A feasibility study / M.A. Richardson, N.C. Russell, T. Sanders [et al.] // J. Altern. Complement. Med. – 2001; 7: 19–32.

Rosenkranz, V. Alkaloids induce programmed cell death in bloodstream forms of trypanosomes (Trypanosoma b. brucei) Molecules / V. Rosenkranz, M. Wink. – 2008; 13: 2462–2473.

Rousseau, J. Ethnobotanique ab?naklse / J. Rousseau // Arch. Folk. – 1947; 11: 145–182.

Anti-thrombotic and anti-inflammatory activities of protopine / S. Saeed, A. Gilani, R. Majoo, B. Shah // Pharmacol. Res. – 1997; 36: 1–7.

Salmore, A.K. Environmental and genotypic influences on isoquinoline alkaloid content in Sanguinaria Canadensis / A.K. Salmore, M.D. Hunter // J. Chem. Ecol. – 2001; 27: 1729–1747. – doi: 10.1023/A:1010448406809.

Choline kinase inhibition induces exacerbated endoplasmic reticulum stress and triggers apoptosis via chop in cancer cells / E. Sanchez-Lopez, T. Zimmerman, T. Gomez del Pulgar [et al] // Cell Death Dis. – 2013; 4: e933.

Sanguinaria canadensis // FNA (Flora of North America). – Vol. 30. - Family List. - Papaveraceae. – Sanguinaria [Электронный ресурс]. – Доступ: http://efloras.org/florataxon.aspx?flora_id=1&taxon_id=220011939 (по состоянию на 05.11.2019).

Inhibitory effect of isoquinoline alkaloids on movement of second-stage larvae of Toxocara canis / T. Satou, N. Akao, R. Matsuhashi [et al.] // Biol. Pharm. Bull. – 2002; 25: 1651–1654.

Assay of nematocidal activity of isoquinoline alkaloids using third-stage larvae of Strongyloides ratti and S. Venezuelensis / T. Satou, M. Koga, R. Matsuhashi [et al.] // Vet. Parasitol. – 2002; 104: 131–138.

Glomerular mesangial cells and inflammatory macrophages ingest neutrophils undergoing apoptosis / J. Savill, J. Smith, C. Sarraf [et al.] // Kidney Int. – 1992; 42: 924–936.

Strongyloides stercoralis: Global distribution and risk factors / F. Sch?r, U. Trostdorf, F. Giardina [et al.] // PLoS Negl. Trop. Dis. – 2013; 7: 1414.

Schilcher, H. Phytotherapy in Paediatrics – Handbook for Physicians and Pharmacists / H. Schilcher. 2nd German ed. translated by A.R. Meus, Medical Pharmacy Publishers, Stuttgart, 1997.

Schmeller, T. Biochemical activities of berberine, palmatine and sanguinarine mediating chemical defence against microorganisms and herbivores / T. Schmeller, Latz-Br?ning B., Wink M. // Phytochemistry. – 1997; 44: 257–266.

Seifen, E. Sanguinarine: A positive inotropic alkaloid which inhibits cardiac Na+, K+-ATPase / E. Seifen, R.J. Adams, R.K. Riemer // Eur. J. Pharmacol. – 1979; 60: 373–377.

Segarra-Newnham, M. Manifestations, diagnosis, and treatment of strongyloides stercoralis infection / M. Segarra-Newnham // Ann. Pharmacother. – 2007; 41: 1992–2001.

Sanguinarine interacts with chromatin, modulates epigenetic modifications, and transcription in the context of chromatin / B.R. Selvi, S.K. Pradhan, J. Shandilya [et al.] // Chem. Biol. 2009. – 16: 203–216.

Bloodroot (Sanguinaria Canadensis L., papaveraceae) enhances proliferation and cytokine production by human peripheral blood mononuclear cells in an in vitro model / D.S. Senchina, G.N. Flinn, D.A. McCann [et al.] // J. Herbs Spices Med. Plants. – 2009; 15: 45–65.

?ener, B. Discovery of drug candidates from some turkish plants and conservation of biodiversity / B. ?ener, ?. Orhan // Pure Appl. Chem. 2005; 77: 53–64.

Seubert, J. Synthesis and properties of praziquantel, a novel broad spectrum anthelmintic with excellent activity against schistosomes and cestodes / J. Seubert, R. Pohlke, F. Loebich // Experientia. – 1977; 33: 1036–1037.

Shaw, A.D.M.C. Editorial. West. Lancet Mon. / A.D.M.C. Shaw, C.H. Moore, M. Henry // J. Pract. Med. Surg. – 1857; 18: 541–542.

Shemon, A.N. Chelerythrine and other benzophenanthridine alkaloids block the human P2X7 receptor / A.N. Shemon, R. Sluyter, A.D. Conigrave, J.S. Wiley // Br. J. Pharmacol. – 2004; – 142: 1015–1019.

Molecular signatures of sanguinarine in human pancreatic cancer cells: A large scale label-free comparative proteomics approach / C.K. Singh, S. Kaur, J. George [et al.] // Oncotarget. – 2015; 6: 10335–10348.

Investigation of the inhibitory effects of chelerythrine chloride on the translocation of the protein kinase c ?i, ?ii, ? in human neutrophils / X. Siomboing, B. Gressier, T. Dine [et al.] // IL Farmaco. – 2001; 56: 859–865.

Sivyer, G.W. Application of black salve to a thin melanoma that subsequently progressed to metastatic melanoma: A case study / G.W. Sivyer, C. Rosendahl // Dermatol. Pract. Concept. – 2014; 4: 77–80.

Antitumour activities of sanguinarine and related alkaloids / I. Slaninova, K. Pencikova, J. Urbanova [et al.] // Phytochem. Rev. – 2014; 13:51–68.

Slaninova, I. Quaternary benzo[c]phenanthridine alkaloids – Novel cell permeant and red fluorescing DNA probes / I. Slaninova, J. Slanina, E. Taborska // Cytom. A. – 2007; 71: 700–708.

Screening of minor benzo[c]phenanthridine alkaloids for antiproliferative and apoptotic activities / I. Slaninova, Z. Slunska, J. Sinkora [et al.] // Pharm. Biol. – 2007 – 45: 131–139.

Slaninov?, I. Interaction of benzo[c]phenanthridine and protoberberine alkaloids with animal and yeast cells / I. Slaninov?, E. T?borsk?, H. Bocho??kov?, J. Slanina // Cell Biol. Toxicol. – 2001; 17: 51–63.

Effect of quaternary benzo[c]phenanthridine alkaloids sanguilutine and chelilutine on normal and cancer cells / Z. Slunska, E. Gelnarova, J. Hammerova [et al.] // Toxicol. in Vitro. – 2010; 24: 697–706.

Smith, D.B. On Sanguinaria Canadensis / D.B. Smith // Boston Med. Surg. J. – 1832; 5: 393–395.

Smith, H.H. Ethnobotany of the Meskwaki Indians / H.H. Smith. – Milwaukee, WI, USA: Public Museum of the City of Milwaukee, 1928.

Smith, H.H. Ethnobotany of the Forest Potawatomi Indians / H.H. Smith. – New York, NY, USA: AMS Press Inc.; 1933. – Р.175–326.

Sollenberger, R.R. Rappahannock field notes / R.R. Sollenberger // Am. Philos. Soc. 1940.

Electrophysiological effects of protopine in cardiac myocytes: Inhibition of multiple cation channel currents / L.S. Song, G.J. Ren, Z.L. Chen [et al.] // Br. J. Pharmacol. – 2000; 129: 893–900.

Speck, F.G. Medicine practices of the Northeastern Algonquians / F.G. Speck. – Washington, DC, USA: International Congress of Americanists, 1917. – Р.318.

Still?, A. Therapeutics and Materia Medica / A. Still?. Volume 2. – Philadelphia, PA, USA: Blanchard and Lea, 1874. – Р.454–457.

Strachey W. The Historie of Travaile into Virginia Britannia / W. Strachey. – London, UK: Hakluyt Society, 1849. – P.64.

Chelerythrine chloride induces rapid polymorphonuclear leukocyte apoptosis through activation of caspase-3 / J.F. Sweeney, P.K. Nguyen, K.B. Atkins, D.B. Hinshaw // Shock. – 2000; 13: 464–471.

Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase / I. Tan, J. Lai, J. Yong [et al.] // FEBS Lett. – 2011; 585: 1260–1268.

Influence of natural and synthetic compounds on cell surface expression of cell adhesion molecules, ICAM-1 and VCAM-1 / S. Tanaka, Y. Sakata, K. Morimoto [et al.] // Planta Med. – 2001; 67: 108–113.

Tang, M. Important roles for l-selectin and icam-1 in the development of allergic airway inflammation in asthma / M. Tang, L. Fiscus // Pulm. Pharmacol. Ther. – 2001; 14: 203–210.

Tantaquidgeon, G. A Study of Delaware Indian Medicine Practice and Folk Beliefs / G. Tantaquidgeon. – Harrisburg, PA, USA: Commonwealth of Pennsylvania, Departmet of Public Instruction, Pennsylvania Historical Commission, 1942. – P.32.

Thatcher, J. The American New Dispensatory / J. Thatcher. 2nd ed. – Boston, MA, USA: Thomas B. Wait & Co. and C. Williams, 1813. – Р. 201–204.

Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitors / A.G. Thomas, C. Rojas, C. Tanega [et al.] // Biochem. Biophys. Res. Commun. – 2013; 438: 243–248.

Todor, I. The effect of the antineoplastic drug ukrain on the electrokinetic potential of malignant and normal cells / I. Todor // Int. J. Immunother. – 2003; 19: 159–168.

Trost, L.B. History of mohs surgery / L.B. Trost, P.L. Bailin // Dermatol. Clin. - 2011; 29: 135–139.

In vitro study of the anticholinergic and antihistaminic activities of protopine and some derivatives / ?st?nes L., Laekeman G.M., G?zler B. [et al.] // J. Nat. Prod. – 1988; 51: 1021–1022.

Detailed analysis of the cell infiltrate and the expression of mediators of synovial inflammation and joint destruction in the synovium of patients with psoriatic arthritis: Implications for treatment / A.W. Van Kuijk, P. Reinders-Blankert, T.J. Smeets [et al.] // Ann. Rheum. Dis. – 2006; 65: 1551–1557.

Molecular mechanisms of necroptosis: An ordered cellular explosion / P. Vandenabeele, L. Galluzzi, T.V. Berghe, G. Kroemer // Nat. Rev. Mol. Cell Biol. – 2010; 11: 700–714.

Vavreckova, C. Benzophenanthridine alkaloids of chelidonium majus; I. Inhibition of 5- and 12-lipoxygenase by a non-redox mechanism / C. Vavreckova, I. Gawlik, K. Muller // Planta Med. – 1996; 62: 397–401.

Vlachojannis, C. Rise and fall of oral health products with canadian bloodroot extract / C. Vlachojannis, F. Magora, S. Chrubasik // Phytother. Res. – 2012; 26: 1423–1426.

Vogel, V.J. American Indian Medicine / V.J. Vogel. – Norman, OK, USA: University of Oklahoma Press, 2013.

All tangled up: How cells direct, manage and exploit topoisomerase function / S.M. Vos, E.M. Tretter, B.H. Schmidt, J.M. Berger // Nat. Rev. Mol. Cell Biol. – 2011 – 12: 827–841.

Conventional protein kinase c isoenzymes undergo dephosphorylation in neutrophil-like HL-60 cells treated by chelerythrine or sanguinarine / J. Vrba, Z. Dvorak, J. Ulrichova, M. Modriansky // Cell Biol. Toxicol. 2008; 24:39–53. doi: 10.1007/s10565-007-9014-1.

Sanguinarine is a potent inhibitor of oxidative burst in DMSO-differentiated HL-60 cells by a non-redox mechanism / J. Vrba, Z. Dvorak, J. Ulrichova, M. Modriansky // Chem. Biol. Interact. – 2004; 147: 35–47.

Wang, G.X. In vivo anthelmintic activity of five alkaloids from Macleaya microcarpa (Maxim.) fedde against Dactylogyrus intermedius in Carassius auratus / G.X. Wang, Z. Zhou, D.X. Jiang // Vet. Parasitol. – 2010; 171: 305–313.

Antiplasmodial agents from the bhutanese medicinal plant Corydalis calliantha / P. Wangchuk, J.B. Bremner, R. Rattanajak, S. Kamchonwongpaisan // Phytother. Res. 2010; 24:481–485. doi: 10.1002/ptr.2893.

Watt, G. Dictionary of the Economic Products of India / G. Watt. 6 vols. – Nav Bharat Offset Process, Delhi, India, 1889–1892, reprint 1972.

Wen, L.N. Competitive binding assay for G-quadruplex DNA and sanguinarine based on room temperature phosphorescence of Mn-doped ZnS quantum dots / L.N. Wen, M.X. Xie // J. Photochem. Photobiol. A Chem. – 2014; 279: 24–31.

White, L.B. Kids, Herbs, Health – A Parent’s Guide to Natural Remedies / L.B. White and S. Mavor. – Interweave Press, 1998.

Impairment of function in aging neutrophils is associated with apoptosis / M. Whyte, L.C. Meagher, J. MacDermot, C. Haslett // J. Immunol. – 1993; 150: 5124–5134.

William, T. Sanguinarine and its salts: On the medicinal powers of sanguinarine and its salts / T. William // Boston Med. Surg. J. – 1832; 6: 245–248.

Williamson, E.M. Potter’s New Cyclopaedia of Botanical Drugs and Preparations / E.M. Williamson and F.J. Evans; revised ed., Saffron Walden, the C.W. Daniel Co., Ltd., Essex, UK, 1988, reprint 1989.

Wink, M. Modes of action of allelochemical alkaloids: Interaction with neuroreceptors, DNA, and other molecular targets / M. Wink, T. Schmeller, B. Latz-Bruning // J. Chem. Ecol. – 1998; 24: 1881–1937.

Wolff, J. Antimicrotubule properties of benzophenanthridine alkaloids / J. Wolff, L. Knipling // Biochemistry. – 1993; 32: 13334–13339.

Protective effects of protopine on hydrogen peroxide-induced oxidative injury of PC12 cells via Ca2+ antagonism and antioxidant mechanisms / X. Xiao, J. Liu, J. Hu [et al.] // Eur. J. Pharmacol. – 2008; 591: 21–27.

Study on the alkaloids from the stem of zanthoxylum dissitum / C. Xiao, Y. Yuan, Y.Z. Ding [et al.] // Zhong Yao Cai. – 2011; 34: 551–553.

Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models / L.-F. Xu, W.-J. Chu, X.-Y. Qing [et al.] // Neuropharmacology. – 2006; 50: 934–940.

Chelerythrine rapidly induces apoptosis through generation of reactive oxygen species in Cardiac myocytes / S. Yamamoto, K. Seta, C. Morisco [et al.] // J. Mol. Cell. Cardiol. – 2001; 33: 1829–1848.

Interleukin-1? induces ICAM-1 expression enhancing leukocyte adhesion in human rheumatoid arthritis synovial fibroblasts: Involvement of erk, JNK, AP-1, and NF-?B / C.M. Yang, S.F. Luo, H.L. Hsieh [et al.] // J. Cell. Physiol. – 2010; 224: 516–526.

Yang, D. Structural insights into G-quadruplexes: Towards new anticancer drugs / D. Yang, K. Okamoto // Future Med. Chem. – 2010; 2: 619–646.

Formation of human telomeric G-quadruplex structures induced by the quaternary benzophenanthridine alkaloids: Sanguinarine, nitidine, and chelerythrine / S. Yang, J.F. Xiang, Q.F. Yang [et al.] // Chin. J. Chem. – 2010; 28: 771–780.

Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis by chelerythrine do not require inhibition of protein kinase C. / R. Yu, S. Mandlekar, T.-H. Tan, A.-N.T. Kong // J. Biol. Chem. – 2000; 275: 9612–9619.

Zhang, S.-M. Identification of plumbagin and sanguinarine as effective chemotherapeutic agents for treatment of schistosomiasis / S.-M. Zhang, K.A. Coultas // Int. J. Parasitol. Drugs Drug Resist. – 2013. – 3. – 28–34.

Induction of apoptosis by chelerythrine chloride through mitochondrial pathway and Bcl-2 family proteins in human hepatoma SMMC-7721 cell / Z.-F. Zhang, Y. Guo, J.-B. Zhang, X.-H. Wei // Arch. Pharm. Res. – 2011; 34: 791–800.

Selective targeting of PPAR? by the natural product chelerythrine with a unique binding mode and improved antidiabetic potency / W. Zheng, L. Qiu, R. Wang [et al.] // Sci. Rep. – 2015; 5: 12222.

Опубликован

2020-03-31

Как цитировать

Колман, Н., и Т. Л. Киселева. «САНГВИНАРИЯ КАНАДСКАЯ (SANGUINARIA CANADENSIS L.): Публикация 2: биологическое действие, применение в традиционной медицине и современной мировой медико-фармацевтической практике». Традиционная медицина, вып. 1(60) 2020, март 2020 г., сс. 25-56, http://www.tradmed.ru/index.php/tm/article/view/1496.

Выпуск

Раздел

Натуротерапия

Наиболее читаемые статьи этого автора (авторов)

1 2 3 > >>