The study of anti-inflammatory and antibacterial activities of the herb Picris hieracioides L.

Abstract

An acute toxicity, anti-inflammatory and antibacterial activity of a herb of Picris hieracioides L. were studied. An acute toxicity was studied by the Shtabsky method, as a result of it, it was determined, that infusion of a herb of Picris hieracioides L. is non-toxic. Anti-inflammatory activity of this infusion was studied by influence on the different stages of inflammation process: exudation and proliferation. An anti-exudative activity was explored on the model of acute inflammatory swelling, which was raised by an injection 0,05 ml 2,5 % formaline solution in the mouse hinder leg. For the discovering of proliferative properties we used a model of «cotton granuloma». An anti-inflammatory action of infusion of a herb of Picris hieracioides L. appears in oppression of an exudative (43,17 %) and proliferative stages (59,19 %). An antibacterial activity was determined in vitro on the reference strains of test-cultures: Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia Coli, Proteus vulgaris, Bacillus cereus, Candida. The infusion of herb Picris hieracioides L. has antibacterial activity against Candida and Pseudomonas aeruginosa test culture.