Evidence-based medicine: prospects for homeopathy
Keywords:
homeopathy, evidence base of homeopathy, randomized clinical trials in homeopathyAbstract
The article outlines approaches to planning and conducting clinical trials to form an acceptable evidence base of homeopathic therapy. According to the author, the stumbling block for accepting the results of modern randomized clinical trials (RCTs) of homeopathic medicines is the erroneous application of Avogadro’s law for ideal gases to potentiated solutions and the requirement of randomization in the formation of the sample under study. Variants of clinical research design are proposed that will improve the methodological quality of research without violating the requirements for the organization of RCTs that are used in evidence-based medicine.
References
Абакаров М.Г. Адаптивный ответ: перспективы для понимания механизма действия гомеопатии // Традиционная медицина. – 2014. – 3(38). – С.9–14.
Буралакова Е.Б., Архипова.,Чернавская . Воздействие химических агентов в сверхмалых дозах на биологические объекты / Изв.АН СССР. – 1990. – №2. – С.184–194.
Доказательная медицина. Научно-обоснованная медицинская практика: Монография / Г.П. Котельников, А.С. Шпигель. – Самара; Сам ГМУ, 2000. – С.168.
Зилов В.Г., Судаков К.В., Эпштейн О.И. Элементы информационной биологии и медицины. – М: МГУЛ, 2001. – 248 с.
Лоуренс Д.Р., Беннит П.Н. Клиническая фармакология и фармакотерапия. – 1991, т.1. – 890 с.
Фейнман Р. Внизу полным полно места: приглашение в новый мир физики // Химия и жизнь. – 2002. – №12. – С.20.
Эпштейн О.И., Сверхмалые дозы (история одного исследования). – М.: Издательство РАМН., 2008. – 336 с.
Barnes J., Resch K-L., Ernst E. Homeopathy for postoperative ileus? A meta-analysis // J Clin Gastroenterol 1997; 25: 628–33.
Beghi B.G., Morselli-Labate A.M. Does homeopathic medicine have a preventive effect on respiratory tract infections? A real life observational study Multidisciplinary Respiratory Medicine. – 2016 11:12 DOI 10.1186|s40248-016-0049-0.
Belon P., Cumps J., Ennis M. et al. Histamine dilutions modulate basophil activation // Inflamm Res. – 2004; 53: 181-8.
Colombo G.L., Di Matteo S., Martinotti C., Oselin M., Bruno G.M., Beghi G.M. The preventive effect on respiratory tract infections of Oscillococcinum®. A cost-effectiveness analysis // Clinicoecon Outcomes Res. – 2018 Jan 23;10:75-82. doi: 10.2147/CEOR.S144300. eCollection 2018.
Cucherat M., Haugh M.C., Gooch M., Boissel J.P. Evidence of clinical efficacy of homeopathy – A meta-analysis of clinical trials // Eur J. Clin Pharmacol. – 2000; 56: 27–33.
Ernst E. A systematic review of systematic reviews of homeopathy // Br J. Clin. Pharmacol. – 2002 Dec; 54(6):577-82.
Jacobs J., Jonas W.B., Jimenez-Perez M., Crothers D. Homeopathy for childhood diarrhea: combined results and metaanalysis from three randomized, controlled clinical trials // Pediatr. Infect. Dis. J. 2003; 22: 229-34.
Keller D., Sundrum A. Comparative effectiveness of individualised homeopathy and antibiotics in the treatment of bovine clinical mastitis: randomised controlled trial. Vet Rec. 2018 Apr 7; 182(14):407. doi: 10.1136/vr.104555. Epub 2018 Jan 26.
Marrari L.A., Terzan L. and Chaufferin G. Oscillococcinum for influenza treatment // Ann Ist Super Sanità 2012, Vol. 48. – №1. –105–109.
Mathie R.T., Lloyd S.M., Legg L.A., Clausen J., Moss S., Davidson J.R.T. I. Ford Randomised placebo-controlled trials of individualised homeopathic treatment: systematic review and meta-analysis 2014.
Mathie R.T. Controlled clinical studies of homeopathy // Homeopathy. – 2015 Oct;104(4):328-32. doi: 10.1016/j.homp.2015.05.003.
Mathie R.T., Clausen J. Veterinary homeopathy: meta-analysis of randomised placebo-controlled trials. 2015 jan;104(1):3-8. Doi: 10.1016/j.homp.2014.11.001. Epub 2014 dec
Mathie R.T., Frye J., Fisher P. Homeopathic Oscillococcinum(®) for preventing and treating influenza and influenza-like illness. Cochrane Database Syst Rev. 2012 Dec 12;12:CD001957. doi: 10.1002/14651858.CD001957.pub5.
Shipley M., Berry H., Broster G. et al. Controlled trial of homeopathic treatment of osteoarthritis. Lancet. 1983; 1(8316):97-98.
Vickers A.J., Smith C. Homeopathic Oscillococcinum for pre- venting and treating influenza and influenza-like syndrome (Review). Cochrane Database Syst Rev 2006; 3:CD001957.
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