Antiopisthorchiasis activity of some Siberian flora Centaurea species
Keywords:
Opisthorchis felineus, Centaurea scabiosa, Centaurea pseudomaculosa, Centaurea jaceae, Centaurea Phrygia, sesquiterpene lactones, cynaropicrin, antiopisthorchiasis activityAbstract
In experiments on the golden hamsters-males antiopisthorchiasis activity (with respect to Opisthorchis felineus) of extracts obtained from Centaurea scabiosa L., Centaurea pseudomaculosa Dobrocz., Centaurea jaceae L. and Centaurea phrygia L. Asteraceae family was investigated. Antiopisthorchiasis activity of sesquiterpene lactone guainolide-type cynaropicrin isolated from Centaurea scabiosa L. was confirmed. It’s suggested that sesquiterpene lactones grosshemin and repin has an antihelminthic activity.
References
Opisthorchis felineus and Metorchis bilis are the main agents of liver fluke infection of humans in Russia / V. Mordvinov [et al.] // Parasit. Int. – 2011. – №61. – P.25–31.
P. Olson et al. Phylogeny and classification of the Digenea (Platyhelminthes: Trematoda) // Int. J. Parasitol. – 2003. – Vol.33. – P.733–755.
Огородова Л.М. и др. Описторхоз в РФ. Взгляд на проблему в 21 веке / Науч. ред. Л.М. Огородова, А.Э. Сазонов; М-во здравоохранения РФ, Сиб. гос. мед. ун-т. – Новосибирск: Издательство СО РАН, 2016. – 130 с.
Pozio E. et al. Opisthorchis felineus, an emerging infection in Italy and its implication for the European Union // Acta Tropica. – 2013. – №123. – P.54–62.
Sripa B. et al. Opisthorchiasis and Opisthorchis-associated cholangiocarcinoma in Thailand and Laos // Acta Tropica. – 2011. – № 120S. – P. S158–S168.
Sithithaworn P. et al. The current status of opisthorchiasis and clonorchiasis in the Mekong Basin // Parasit. Int. – 2012. – Vol. 61. – Is. 1. – P.10–16.
A review of human carcinogens. IARC monographs on the evaluation of carcinogenic risks to humans. World Health Organization, International Agency for Research on Cancer IARC Biological agents. – 2012. – Vol. 100 B. – № 100. – 449 P.
Gouveia M. et al. Infection with Opisthorchis felineus induces intraepithelial neoplasia of the biliary tract in a rodent model // Carcinogenesis. – 2017. – Vol. 38. – Is. 9. – P.929–937.
Sut S. et al. New Drugs from Old Natural Compounds: Scarcely Investigated Sesquiterpenes as New Possible Therapeutic Agents // Curr. Med. Chem. – 2018 – Vol. 25 – №10 – P.1241–1258.
Pandey M.M., Rastogi S., Rawat A. K. S. Saussurea costus: botanical, chemical and pharmacological review of an ayurvedic medicinal plant // J. of Ethnopharmacol. – 2007. – №110. – P.379–390.
Krasnov E. et al. Isolation of grosheimin from the Siberian population of Centaurea scabiosa // Chem. of Nat. Comp. – 2006. – Vol. 42. – №4. – P.495–496.
Krasnov E. et al. Isolation of repin from the aerial part of Centaurea scabiosa // Chem. of Nat. Comp. – 2011. – Vol.47. – №2. – P.311–312.
Kaminskii I. et al. Quantitative HPLC determination of cynaropicrin in Centaurea Scabiosa dry extract // Pharm. Chem. J. – 2011. – Vol. 45. – Is. 9. – P.560–563.
Руководство по проведению доклинических исследований лекарственных средств / Под общ. ред. д-ра мед. наук А.Н. Миронова. Часть первая. – М.: Гриф и К. – 2012. − С.445–453.
Бронштейн М.А., Лучшев В.И. Трематодозы печени: описторхоз, клонорхоз // Русский медицинский журнал – 1998. – Т. 6. – № 3. – С.140–148.
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