Lipid-lowering activity of plant polysaccharides
Keywords:
plant polysaccharides, lipid-lowering activity, high-fat diet, cholesterol, simvastatinAbstract
The current study on the hypolipidemic action of the Crataegus sanguinea Pall., Betula pendula Roth., Betula pubescens Ehrh. and Medicago sativa L. polysaccharide complexes was conducted on the model of long-term high-fat cholesterol-rich diet-caused hyperlipidemia in Wistar rats. The birch polysaccharides (1.5 %) addition to the atherogenic diet led to decrease the level of total cholesterol mainly in the proatherogenic fraction of low-density lipoproteins. The cholesterol concentration in the anti-atherogenic fraction of high-density lipoproteins decreased to a lesser extent, while the atherogenic index decreased significantly. Crataegus polysaccharides had a less pronounced lipid-lowering effect, and Medicago sativa polysaccharides did not improve the blood lipid spectrum on the background of a high-fat cholesterol-rich diet. The possible mechanisms of the polysaccharides hypolipidemic action are discussed.
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