АНТИБАКТЕРИАЛЬНАЯ АКТИВНОСТЬ КУРКУМЫ ДЛИННОЙ (CURCUMA LONGA L.)

T.A. Smirnova; Yu.A.  Smirnov; V.G. Zhukhovitsky

doi:10.54296/18186173_2021_1_43

Authors

T.A. Smirnova N.F. Gamaleya Federal Research Center for Epidemiology and Microbiology, Ministry of Health of Russia (Moscow, Russia)
Yu.A. Smirnov N.F. Gamaleya Federal Research Center for Epidemiology and Microbiology, Ministry of Health of Russia (Moscow, Russia)
V.G. Zhukhovitsky N.F. Gamaleya Federal Research Center for Epidemiology and Microbiology, Ministry of Health of Russia (Moscow, Russia)

DOI:

https://doi.org/10.54296/18186173_2021_1_43

Keywords:

curcuma, curcumin, antimicrobial properties, microbes

Abstract

Curcuma longa L. and its compound curcuminoids have pleiotropic activity, including antimicrobial activity. Numerous studies have shown that antimicrobial activities for extracts of Curcuma longa and curcuminoids possesses a wide spectrum of biological and pharmacological properties against different microbes. Mechanisms antimicrobial activity of curcuminoids involve either a direct interference of microbial replication machinery or suppression of cellular signaling pathways essential for microbial replication. This review summarizes the current knowledge and future perspectives of the use of the antimicrobial effects of curcumin.

Author Biography

T.A. Smirnova, N.F. Gamaleya Federal Research Center for Epidemiology and Microbiology, Ministry of Health of Russia (Moscow, Russia)

Д.б.н., ведущий научный сотрудник лаборатории индикации и ультраструктурного анализа микроорганизмов

References

Большой энциклопедический словарь лекарственных растений. – СПб.: Спец Лит., 2015. – 296 с.

Механизмы деления бактериальной клетки / А.Д. Ведяйкин, Е.В. Пономарева, М.А. Ходорковский [и др.] // Микробиология. – 2019; 88(3): 253–271.

Подходы к антивирусной фитотерапии / Ю.А. Смирнов, Т.Л. Киселева, Ю.А. Смирнов, А.А. Карпеев // Традиционная медицина. – 2009; 17(2): 47–59.

Структурно-функциональная характеристика бактериальных биопленок / Т.А. Смирнова, Л.В. Диденко, Р.Р. Азизбекян, Ю.М. Романова // Микробиология.?– 2010; 79 (4):, 435–446.

Смирнов, Ю.А. Антивирусный потенциал куркумы длинной (Curcuma longa L.) / Смирнов Ю.А. // Традиционная медицина. – 2020; 61(2): 12–19.

Соловьёва, Н.Л. Биодоступность куркумина и методы её повышения (обзор) / Н.Л. Соловьёва, М.С. Сокуренко, О.А. Зырянов // Разработка и регистрация лекарственных средств. – 2018; 3:46–53.

Adamczak. Curcumin, a Natural Antimicrobial Agent with Strain-Specific Activity./ Adamczak, M. O?zarowski and T.M. Karpi?nski // Pharmaceuticals. – 2020; 13: 153.

Antimicrobial effects of curcumin against L. monocytogenes, S. aureus, S. Typhimurium and E. coli O157:H7 pathogens in minced meat / S.S. Altunatmaz, F.Y. Aksu, G. Issa [et al.] Buyukunal // Veterinarni Medicina, 61, 2016 (5): 256–262 doi: 10.17221/8880

Amer, F.A. New Targets for Antibacterial Agents / F.A. Amer, E.M. El-Behedy and H.A. Mohtady // Biotechnology and Molecular Biology Reviews. – 2008; 3 (3): 046–057.

Curcumin Nanoparticles: Preparation, Characterization, and Antimicrobial Study / Bhawana, B.R.K. Basniwal, H.S. Buttar [et al.] // J. Agric. Food Chem. – 2011; 59 (5): 2056–2061.

Chandra, M. Antimicrobial Activity of Medicinal Plants against Human Pathogenic Bacteria / M. Chandra // Inter. J. of Biotechnol. and Bioeng. Res. – 2013; 4 (7): 653–658.

Experiences with the shikimate-pathway enzymes as targets for rational drug design / J.R. Coggins, C. Abell, L.B. Evans [et al.] // Biochem. Soc. Trans. – 2003; 31(Pt 3):548–52.

Characterization of monospecies biofilm formation by Helicobacter pylori / S.P. Cole, J. Harwood, R. Lee [et al.] // J. Bacteriol. – 2004; 186: 3124–3132.

Costerton, J.W. Bacterial biofilms: a common cause of persistent infections / J.W. Costerton, P.S. Stewart, E.P. Greenberg // Science. – 1999; 284(5418):1318.

Antimicrobial Activity of Curcumin against Helicobacter pylori Isolates from India and during Infections in Mice / R. De, P. Kundu, S. Swarnakar [et al.] // Antimicrobial agents and chemotherapy. – 2009; 53(4): 1592–1597.

Antimicrobial activity of curcumin in combination with light against Escherichia coli O157 H7 and Listeria innocua: applications for fresh produce sanitation / E.F. De Oliveira, J.V. Tosati, R.V. Tikekar [et al.] // Postharvest Biol. Technol. – 2018; 137: 86–94.10.1016/j.postharvbio.2017.11.014

Synthesis, biological activity and molecular modelling studies of shikimic acid derivatives as inhibitors of the shikimate dehydrogenase enzyme of Escherichia coli / D.C. D?az-Quiroz, C.S. Cardona-F?lix, J.L. Viveros-Ceballos [et al.] // J. of enz. inhib. a. med. chem. – 2018; 33(1): 397–404.

Gunes, H. Antibacterial effects of curcumin: An in vitro minimum inhibitory concentration study/ H. Gunes, D. Gulen, R. Mutlu // Toxicology and Industrial Health. – 2016; 32(2): 246–256.

Discovery of Curcumin, a Component of the Golden Spice, and Its Miraculous Biological Activities / S.C. Gupta, S. Patchva, W. Koh and B.B. Aggarwal // Clin. Exp. Pharm. Physiol. – 2012; 39(3): 283–299.

Gupta, A. Evaluation of antimicrobial activity of Curcuma longa rhizome extract against Staphylococcus aureus / Gupta A., S. Mahajan, R. Sharma // Biotech. Rep.?– 2015; 6: 51–55.

The biofilm inhibition and eradication activity of curcumin againts polymicrobial biofilm / H. Hamzah, T. Hertiani, S.U.T. Pratiwi [et al.] // BIO Web of Conferences 28, 04001 (2020) https://doi.org/10.1051/ bioconf/20202804001.

Biochemical characterization and inhibitor discovery of shikimate dehydrogenase from Helicobacter pylori / C. Han, L. Wang, K.Yu [et al.] // FEBS J. – 2006; 273(20):4682–92.

Hu, P. Curcumin reduces Streptococcus mutans biofilm formation by inhibiting sortase A activity / P. Hu, P. Huang, M.W. Chen // Arch. Oral Biol.-2013; 58:1343–1348. 10.1016 / j.archoralbio.2013.05.004

Jaiswal, S. Antimicrobial and antibiofilm activity of curcumin-silver nanoparticles with improved stability and selective toxicity to bacteria over mammalian cells / S. Jaiswal, P. Mishra // Med. Microbiol. Immunol. – 2018; 207: 39–53. 10.1007/s00430-017-0525-y

Curcumin-A Review of Its Antibacterial Effect / K. Kai, W. Bi, Y. Bo [et al.] // Biomed. J. of Sci.. and Tech. Res. – 2020; 26(1):19585-7.

Antibacterial synergy of curcumin with antibiotics against biofilm producing clinical bacterial isolates / A. Kali, D. Bhuvaneshwar, P.M. Charles, K.S. Seetha // J. Basic. Clin. Pharma. – 2016; 7:93-6.

Probing the binding site of curcumin in Escherichia coli and Bacillus subtilis FtsZ – A structural insight to unveil antibacterial activity of curcumin / S. Kaur, N.H. Modi, D. Panda, N. Roy // Eur. J. of Med. Chem. – 2010; 45 (9): 4209–4214.

Helicobacter pylori Infection Activates NF-kB in Gastric Epithelial Cells / S. Keates, Y.S. Hitti, M. Upton and C.N.P. Kelly // Gastroenterology. – 1997;113:1099 –1109.

A study on antibacterial property of curcuma longa?– herbal and traditional medicine / M. Kumar, P. Kaur, R. Garg [et al.] // Adesh Univ J. Med Sci Res. – 2020; 2(2):103-8.

Curcumin as a Promising Antibacterial Agent: Effects on Metabolism and Biofilm Formation in S. mutans / B. Li, X. Li, H. Lin and Y. Zhou // BioMed Res. Inter. – 2018; Article ID 4508709, 11 pages.

Maeda, H. The Shikimate Pathway and Aromatic Acid Biosynthesis in Plants / H. Maeda and N. Dudareva // Ann. Rev. of Plant Biol. – 2012; 63: 73–105.

In vitro susceptibility of Helicobacter pylori to botanical extracts used traditionally for the treatment of gastrointestinal disorders / G.B. Mahady, S.L. Pendland, A. Stoia [et al.] // Phytother. Res. – 2005. 19: 988–991.

Curcumin Reduces the Motility of Salmonella enterica Serovar Typhimurium by Binding to the Flagella, Thereby Leading to Flagellar Fragility and Shedding / S.A. Marathe, A. Balakrishnan, V.D. Negi [et al.] // J. of Bacteriol. – 2016; 198 (1): 1798–1811.

Antibioflm activity of flavonoids on staphylococcal biofilms through targeting BAP amyloids / L. Matilla Cuenca, C. Gil, S. Cuesta, [et al.] // Sci. Rep. – 2020. 3;10(1):18968. doi: 10.1038/s41598-020-75929-2.

Mendez-Vilas A. Science and Technology Against Microbial Pathogens: Research, Development and Evaluation / A. Mendez-Vilas // Proceedings of the International Conference on Antimicrobial Research. – 2010; 92.

Miller, M.B. Quorum sensing in bacteria / M.B. Miller, B.L. Bassler // Annu. Rev. Microbiol. – 2001; 55:165–199.

Mody, D. Curcumin: A natural derivative with antibacterial activity against Clostridium difficile / D. Mody, A.I.M. Athamneh, M.N. Seleem // J. of Glob. Antimicrobial Resistance. – 2020; 21: 154–161.

A Review on Antibacterial, Antiviral, and Antifungal Activity of Curcumin / S.Z. Moghadamtousi, H.A. Kadir, P. Hassandarvish [et al.] // BioMed Res. Inter. – 2014, Article ID 186864, 12 pages.

A simplified curcumin targets the membrane of Bacillus subtilis / L.G. Mor?o, C.R. Polaquini, M. Kopacz [et al.].//Microbiology Open. – 2018; e683. https://doi.org/10.1002/mbo

Protective mechanism of curcumin against Vibrio vulnificus infection / H.S. Na, M.H. Cha, D.-R. Oh [et al.] // FEMS Immunol. Med. Microbiol. – 2011; 63: 355–362.

Antibacterial activity of Curcuma Longa varieties against different strains of bacteria / S. Naz, S. Jabeen, S. I. F. Manzoor [et al.] // Pak. J. Bot. – 2010; 42(1): 455–462.

Curcumin and Its Derivatives: A Review of Their Biological Activities / M.K. Oglah, Y.F. Mustafa, M.K. Bashir, M.H. Jasim // Sys. Rev. Pharm. – 2020; 11(3): 472–481.

Inhibition of biofilm development of uropathogens by curcumin – an anti-quorum sensing agent from Curcuma longa / I.A.S.V. Packiavathy, S. Priya, S.K. Pandian, A.V. Ravi // Food Chem. – 2014;148:453–60.

Pandey, D. Antibacterial efficacy of Curcuma caesia from Bastar district of Chhattisgarh, India / D. Pandey and A.K. Gupta // Int. J. Pharm. Sci. Res. – 2014; 5(6): 2294-01.

Curcuma longa L. constituents inhibit sortase A and Staphylococcus aureus cell adhesion to fibronectin / B.-S. Park, J.-G. Kim, M. Kim [et al.] // J. Agric. Food Chem. – 2005; 53: 9005–9009. 10.1021/jf051765z

Effect of Non Antibiotic Antimicrobial Curcuma Longa on Helicobacter Pylori Infection / Patil T.R., Patil S.T., Patil S. and Patil A. // Int. J. Pharmacogn. Chinese Med. – 2018; 2(5): 000150.

Pattiyathanee, P. Effect of curcumin on Helicobacter pylori biofilm formation./ P. Pattiyathanee, R.-korn Vilaichone and N. Chaichanawongsaroj // African J. of Biotechnol. – 2009; 8 (19): 5106-5115.

Pravin Charles, M.V. Inhibitory Effect of Curcumin on Biofilm Produced by Bacterial Pathogens / M.V. Pravin Charles, A. Kali, Bhuvaneshwar and K.S. Seetha // Inter. J. of Current Microbiol. and App. Sci. – 2016; 5 (12): 692–697.

Curcumin inhibits FtsZ assembly: an attractive mechanism for its antibacterial activity / D. Rai, J.K. Singh, N. Roy, D. Panda // Biochem J. – 2008;410(1): 147–155.

Ratrey, P. Enhancing Aqueous Solubility and Antibacterial Activity of Curcumin by Complexing with Cell-Penetrating Octaarginine / P. Ratrey, S. V. Dalvi and A. Mishra // ACS Omega. – 2020; 5: 19004–19013.

Rudrappa, T. Curcumin, a Known Phenolic from Curcuma longa, Attenuates the Virulence of Pseudomonas aeruginosa PAO1 in Whole Plant and Animal Pathogenicity Models / T. Rudrappa and H.P. Bais // J. Agric. Food Chem.?– 2008; 56 (6): 1955–1962.

Sarkar, A. Curcumin as a potential therapeutic candidate for Helicobacter pylori associated diseases / A. Sarkar, R. De, A.K. Mukhopadhyay // World J. Gastroenterol. – 2016; 7;22(9):2736-48.

The mode of antimicrobial action of curcumin depends on the delivery system: monolithic nanoparticles vs. supramolecular inclusion complex / Shlar, S. Droby, R. Choudharyc and V. Rodov // RSC Adv. – 2017; 7: 42559–42569.

Silva, N.C.C., Fernandes J?nior A. Biological properties of medicinal plants: a review of their antimicrobial activity / N.C.C. Silva, A. Fernandes J?nior // J. Venom. Anim. Toxins incl Trop Dis. – 2010; 16 (3): 402–419.

Curcumin suppresses gastric NF-kB activation and macromolecular leakage in Helicobacter pylori-infected rats / K. Sintara, D. Thong-Ngam, S. Patumraj [et al.] // World J. Gastroenterol. – 2010; 16(32): 4039–4046.

Antibacterial Activity of Curcumin in Combination with Tetracycline Against Staphylococcus aureus by Disruption of Cell Wall / E.Y. Sukandar, N.F. Kurniati, K. Puspatriani and H.P. Adityas // Res. J. Med. Plants. – 2018; 12 (1): 1–8.

Antibacterial Action of Curcumin against Staphylococcus aureus / S.-Y. Teow, K. Liew, S.A. Ali [et al.] // J. of Tropical Medicine. – 2016, Article ID 2853045, 10 pages.

Bactericidal Activity of Curcumin I Is Associated with Damaging of Bacterial Membrane / P. Tyagi, M. Singh, H. Kumari [et al] // PLoS ONE. – 2015; 10(3): e0121313.

Vetvicka, V. Effects of curcumin on Helicobacter pylori infection / V. Vetvicka, J. Vetvickova, R. Fernandez-Botran // Ann. Transl. Med. – 2016; 4(24):479. doi: 10.21037/ atm.2016.12.52.

Sticking together: building a biofilm the Bacillus subtilis way / H. Vlamakis, Y. Chai, P. Beauregard [et al.] // Nat Rev Microbiol. – 2013; 11(3): 157–168.