Prospects for the use of medicinal raw materials of Lycium barbarum L. in geriatric practice
DOI:
https://doi.org/10.54296/18186173_2024_2_19Keywords:
Lycium barbarum L., medicinal properties, therapy and prevention of age-related diseasesAbstract
The aim of the review is to summarize and analyze the experimental data on the pharmacological properties of Lycium barbarum L., which can be used in geriatric practice in the therapy of age-related diseases. Analysis of publications indicates that the fruits of this plant or their individual components (polysaccharides, etc.) are able to increase the life span of laboratory animals, have antioxidant, neuroprotective, anti-inflammatory effects. Experimentally established effects are of interest for the therapy of such age-related syndromes as Alzheimer's and Parkinson's diseases, osteoarthritis, age-related macular degeneration, senile cataract, etc. The effects of these effects are of interest for the treatment of such age-related syndromes as Alzheimer's and Parkinson's diseases. In this connection, it is stated that the fruits of this plant should be more widely used in geriatric practice for therapy and prevention of a number of age-related diseases.
References
Березуцкий, М.А. Нейробиологические эффекты тенуигенина и перспективы его применения в терапии болезней Альцгеймера и Паркинсона (обзор литературы) / М.А. Березуцкий, Н.А. Дурнова, Л.Е. Сигарёва // Успехи геронтологии, 2021. – Т. 34. – № 2. – С.210–216.
Снарская, Е.С. Фотостарение кожи: современные аспекты / Е.С. Снарская // Вестник дерматологии и венерологии, 2011. – № 2. – С.98–103.
Трубицын, А.Г. Объединенная теория старения / А.Г. Трубицын // Успехи геронтологии, 2012. – Т. 25. – № 4. – С.563–581.
Almeida, S. Are polyphenols strong dietary agents against neurotoxicity and neurodegeneration? / S. Almeida, M.G. Alves, M. Sousa // Neurotoxicity research, 2016. – Vol. 30. – P.345–366.
Amagase, H. Lycium barbarum (goji) juice improves in vivo antioxidant biomarkers in serum of healthy adults / H. Amagase, B. Sun, C. Borek // Nutrition Research, 2009. – Vol. 29. – № 1. – P.19–25.
Asbell, P.A. Age-related cataract / P.A. Asbell, I. Dualan, J. Mindel // The Lancet, 2005. – Vol. 365. – № 9459. – P.599–609.
Beatty, S. The role of oxidative stress in the pathogenesis of age-related macular degeneration / S. Beatty, H. Koh, M. Phil // Survey of Ophthalmology, 2000. – Vol. 45. – № 2. – P.115–134.
Cai, S. Lycium barbarum polysaccharide inhibits NF-?B pathway to reduce the level of inflammatory cytokines in osteoarthritis chondrocytes / S. Cai, J. Sun, X.Wei // Xi bao yu fen zi Mian yi xue za zhi= Chinese Journal of Cellular and Molecular Immunology, 2018. – Vol. 34. – № 11. – P.989–993.
Chang, R.C.C. Use of anti-aging herbal medicine, Lycium barbarum, against aging-associated diseases. What do we know so far? / R.C.C. Chang, K.F. So // Cellular and Molecular Neurobiology, 2008. – Vol. 28. – P.643–652.
Chen, B. Astragaloside IV controls collagen reduction in photoaging skin by improving transforming growth factor-?/Smad signaling suppression and inhibiting matrix metalloproteinase-1 / B. Chen, R. Li, N. Yan // Molecular Medicine Reports, 2015. – Vol. 11. – № 5. – P.3344–3348.
Chen, W. Lycium barbarum polysaccharides prevent memory and neurogenesis impairments in scopolamine-treated rats / W. Chen, X. Cheng, J. Chen // PLoS One, 2014. – Vol. 9. – № 2. – P. e88076.
Gao, Y. Lycium barbarum: a traditional Chinese herb and a promising anti-aging agent / Y. Gao, Y. Wei, Y. Wang // Aging and disease, 2017. – Vol. 8. – № 6. – P.778–791.
Ho, Y.S. Characterizing the neuroprotective effects of alkaline extract of Lycium barbarum on beta-amyloid peptide neurotoxicity / Y.S. Ho, M.S. Yu, C.S. Lai // Brain Research, 2007. – Vol. 1158. – P.123–134.
Hu, X. Investigation of the neuroprotective effects of Lycium barbarum water extract in apoptotic cells and Alzheimer’s disease mice / X. Hu, Y. Qu, Q. Chu // Molecular Medicine Reports, 2018. – Vol. 17. – № 3. – P.3599–3606.
Jing, L. Lycium barbarum polysaccharide arbitrates palmitate-induced apoptosis in MC3T3?E1 cells through decreasing the activation of ERS?mediated apoptosis pathway / L. Jing, X.W. Jia // Molecular medicine reports, 2018. – Vol. 17. – № 2. – P.2415–2421.
Kwok, S.S. A systematic review of potential therapeutic use of Lycium barbarum polysaccharides in disease / S.S. Kwok, Y. Bu, A.C.Y. Lo // BioMed research international, 2019. – Vol. 2019. – P.4615745.
Li, X.M. Protective effect of Lycium barbarum polysaccharides on streptozotocin-induced oxidative stress in rats / X.M. Li // International journal of biological macromolecules, 2007. – Vol. 40. – № 5. – P.461–465.
Li, X.M. Evaluation of antioxidant activity of the polysaccharides extracted from Lycium barbarum fruits in vitro / X.M. Li, X.L. Li, A.G. Zhou // European Polymer Journal, 2007. – Vol. 43. – № 2. – P.488–497.
Li, X.M. Effect of the Lycium barbarum polysaccharides on age-related oxidative stress in aged mice / X.M. Li, Y.L. Ma, X.J. Liu // Journal of ethnopharmacology, 2007. – Vol. 111. – № 3. 504–511.
Li, X.L. Evaluation of the antioxidant effects of polysaccharides extracted from Lycium barbarum / X.L. Li, A.G. Zhou // Medicinal Chemistry Research, 2007. – Vol. 15. – № 9. – P.471–482.
Lin, C.L. Antioxidative activity of polysaccharide fractions isolated from Lycium barbarum Linnaeus / C.L. Lin, C.C. Wang, S.C Chang. // International journal of biological macromolecules, 2009. – Vol. 45. – № 2. – P.146–151.
Liu, J. A polysaccharide from Lycium barbarum L.: Structure and protective effects against oxidative stress and high-glucose-induced apoptosis in ARPE-19 cells / J. Liu, Y. Li, Q Pu. // International Journal of Biological Macromolecules, 2022. – Vol. 201. – P.111–120.
Liu, J. Preparative separation of flavonoids from Goji berries by mixed-mode macroporous adsorption resins and effect on A?-expressing and anti-aging genes / J. Liu, J. Meng, J. Du // Molecules, 2020. – Vol. 25. – № 15. – P.3511.
Liu, L. Lycium barbarum polysaccharides protected human retinal pigment epithelial cells against oxidative stress-induced apoptosis / L. Liu, W. Lao, Q.S. Ji // International journal of ophthalmology, 2015. – Vol. 8. – № 1. – P.11–16.
Long, J.M. Alzheimer Disease: An Update on Pathobiology and Treatment Strategies / J.M. Long, D.M. Holtzman // Cell, 2019. – Vol. 179. – № 2. – P.312–339.
Luo, Q. Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum / Q. Luo, Y. Cai, J. Yan // Life sciences, 2004. – Vol. 76. – № 2. – P.137–149.
Miller, D.B. Biomarkers of Parkinson’s disease: present and future / D.B. Miller, J.P. O’Callaghan // Metabolism, 2015. – Vol. 301. – P.40–60.
Ni, H. Lycium barbarum polysaccharide alleviates IL-1?-evoked chondrogenic ATDC5 cell inflammatory injury through mediation of microRNA-124 / H. Ni, G. Wang, Y Xu. // Artificial Cells, Nanomedicine, and Biotechnology, 2019. – Vol. 47. – № 1. – P.4046–4052.
Ni J. Lycium barbarum polysaccharides in ageing and its potential use for prevention and treatment of osteoarthritis: a systematic review / J. Ni, M. Au, H. Kong // BMC Complementary Medicine and Therapies, 2021. – Vol. 21. – P.1–16.
Niu, Y. Flavonoids from Lycium barbarum Leaves Exhibit Anti-Aging Effects through the Redox-Modulation / Y. Niu, J. Liao, H. Zhou // Molecules, 2022. – Vol. 27. – № 15. – P.4952.
Niu, Y. Distinct Role of Lycium barbarum L. Polysaccharides in Oxidative Stress-Related Ocular Diseases / Y. Niu, G. Zhang, X. Sun // Pharmaceuticals, 2023. – Vol. 16. – № 2. – P.215.
Poulet, B. Gene array profiling of articular chondrocytes in mice with different susceptibility to natural disease reveals specific gene signatures linked to healthy ageing and spontaneous OA / B. Poulet, U. Veronica, T.C. Stone // Osteoarthritis and Cartilage, 2012. – Vol. 20. – P.59– 60.
Qi, B. Lycium barbarum polysaccharides protect human lens epithelial cells against oxidative stress–induced apoptosis and senescence / B. Qi, Q. Ji, Y. Wen // PLoS One, 2014. – Vol. 9. – № 10. – P.e110275.
Protective effects and molecular mechanism of total flavonoids from Lycium Barbarum Leaves on photoaged human dermal fibroblasts / F. Song, L. Wang, J. Mu, H. Ma // Evidence-based Complementary and Alternative Medicine, 2022. – Vol. 2022. – P.4156330
Song, J. Lycium barbarum polysaccharide improves dopamine metabolism and symptoms in an MPTP-induced model of Parkinson’s disease / J. Song, L. Liu, Z. Li // BMC medicine, 2022. – Vol. 20. – № 1. – P.1–12.
Stegemann, S. Geriatric drug therapy: Neglecting the inevitable majority / S. Stegemann, F. Ecker, M. Maio // Ageing research reviews, 2010. – Vol. 9 – № 4. – P.384–398.
Sulzer, D. The physiological role of ??synuclein and its relationship to Parkinson’s Disease / D. Sulzer, R.H. Edwards // Journal of neurochemistry, 2019. – Vol. 150. – № 5. – P.475–486.
Tang, R. Lycium barbarum polysaccharides extend the mean lifespan of Drosophila melanogaster / R. Tang, X. Chen, T. Dang // Food & function, 2019. – Vol. 10. – № 7. – P.4231–4241.
Tang, T. Treatment of d-galactose induced mouse aging with Lycium barbarum polysaccharides and its mechanism study / T. Tang, B. He // African Journal of Traditional, Complementary and Alternative Medicines, 2013. – Vol. 10. – № 4. – P.12–17.
Lycium barbarum Berries (Solanaceae) as Source of Bioactive Compounds for Healthy Purposes: A Review / F. Teixeira, A.M. Silva, C. Delerue-Matos, F. Rodrigues // International Journal of Molecular Sciences, 2023. – Vol. 24. – № 5. – P.4777.
Isolation of carotenoids, flavonoids and polysaccharides from Lycium barbarum L. and evaluation of antioxidant activity / C.C. Wang, S.C. Chang, B.S. Inbaraj, B.H. Chen // Food chemistry, 2010. – Vol. 120. – № 1. – P.184–192.
Wang, C. Research advances on antioxidation, neuroprotection, and molecular mechanisms of Lycium barbarum polysaccharides / C. Wang, L. Zhou, M. Mo //Brain Science Advances, 2021. – Vol. 7. – № 4. – P.207–219.
Wang, J. Ginkgolide B?induced AMPK pathway activation protects astrocytes by regulating endoplasmic reticulum stress, oxidative stress and energy metabolism induced by A?1?42 / J. Wang, Y. Ding, L. Zhuang // Molecular Medicine Reports, 2021. – Vol. 23. – № 6. – P.457.
Wang, X. Lycium barbarum polysaccharide promotes nigrostriatal dopamine function by modulating PTEN/AKT/mTOR pathway in a methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) murine model of Parkinson’s disease / X. Wang, L. Pang, Y. Zhang // Neurochemical research, 2018. – Vol. 43. – P.938–947.
Wang, Z. The anti-aging activity of Lycium barbarum polysaccharide extracted by yeast fermentation: In vivo and in vitro studies / Z. Wang, Q. Sun, J. Fang // International Journal of Biological Macromolecules, 2022. – Vol. 209. – P.2032–2041.
Wojdy?o, A. Phenolic and carotenoid profile of new goji cultivars and their anti-hyperglycemic, anti-aging and antioxidant properties / A. Wojdy?o, P. Nowicka , P. B?belewski // Journal of functional foods, 2018. – Vol. 48. – P.632–642.
Woolf, A.D. Burden of major musculoskeletal conditions / A.D. Woolf, B. Pfleger // Bulletin of the world health organization, 2003. – Vol. 81. – № 9. – P.646–656.
Neuro-protective mechanisms of Lycium barbarum / X. Xing, F. Liu, J. Xiao, K.F. So // Neuromolecular medicine, 2016. – Vol. 18. – P.253–263.
The anti-aging effect of Lycium barbarum polysaccharide on human retinal pigment epithelial cell / D.U. Xiu-juan, D. Wei-hong, B.I. Hong-sheng, X. Xiao-feng // Chinese Journal of Experimental Ophthalmology, 2013. – Vol. 31. – № 8. – P.739–743.
Yang, D. Lycium barbarum extracts protect the brain from blood-brain barrier disruption and cerebral edema in experimental stroke / D. Yang, S.Y. Li, C.M. Yeung // PloS one, 2012. – Vol. 7. – № 3. – P.e33596.
Yu, M.S. Neuroprotective effects of anti-aging oriental medicine Lycium barbarum against ?-amyloid peptide neurotoxicity / M.S. Yu, S.K.Y. Leung, S.W. Lai // Experimental gerontology, 2005. – Vol. 40. – № 8-9. – P.716–727.
Yu, Y. Lycium barbarum polysaccharide protects against oxygen glucose deprivation/reoxygenation-induced apoptosis and autophagic cell death via the PI3K/Akt/mTOR signaling pathway in primary cultured hippocampal neurons / Y. Yu, X. Wu, J. Pu // Biochemical and Biophysical Research Communications, 2018. – Vol. 495. – № 1. – P.1187–1194.
Zheng, J. Lycium barbarum glycopetide prolong lifespan and alleviate Parkinson’s disease in Caenorhabditis elegans / J. Zheng, Z. Luo, K. Chiu // Frontiers in Aging Neuroscience, 2023. –Vol. 15. – P.1156265.
Zheng, X. Protective effects of Lycium barbarum polysaccharide on ovariectomy?induced cognition reduction in aging mice / X. Zheng, J. Wang, F. Bi // International Journal of Molecular Medicine, 2021. – Vol. 48. – № 1. – P.1–13.
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