Therapeutic efficiency of herbal remedy «Dig-da-shi-tan» in complex therapy of alcoholic damage of liver in patients with cronic alcoholism

Abstract

Pharmacotherapeutical efficiency of herbal remedy «Dig-da-shi-tan» have been studied in clinic. Two groups of patients less than 5 year, and more than 5 year of disease were observed. Within each group two subgroups (A and B) were formed. Patients of A subgroup took «Dig-da-shi-tan», patients of B subgroup did not take «Dig-da-shi-tan». All patients were simultaneously treated with antitoxic drug. No other hepatopoprotective drugs were applied. The functional condition of patients’ liver was estimated by enzyme activity in blood serum: alanine aminotransferase (ALT), aspartate aminotransferase (AAT), acid phosphotase (AP), ?-glutamine transferase (GGT). The content of cholesterol, creatinine and total bilirubin was also determined. Antioxidant activity of «Dig-da-shi-tan» was estimated by the content of malondialdehyde and catalase activity in blood serum. Thus it has been found that «Dig-da-shi-tan» showed strong hepatoprotective activity, providing stabilization of membrane structures of hepatocytes and preventing the development of cytolysis and cholestasis.