Antioxidant activity of extracts from species of genus Prunella L.: in vitro and in vivo investigation

Authors

  • A.A. Shamilov Pyatigorsk Medical-Pharmaceutical Institute - Branch of Volgograd State Medical University (Pyatigorsk, Russia)
  • D.I. Pozdnyakov Pyatigorsk Medical-Pharmaceutical Institute - Branch of Volgograd State Medical University (Pyatigorsk, Russia)
  • N.V. Bubenchikova Kursk State Medical University (Kursk, Russia)
  • M.V. Chernikov Pyatigorsk Medical-Pharmaceutical Institute - Branch of Volgograd State Medical University (Pyatigorsk, Russia)
  • E.K. Garsiya Pyatigorsk Medical-Pharmaceutical Institute - Branch of Volgograd State Medical University (Pyatigorsk, Russia)

Keywords:

antioxidants, antioxidant activity, aerial part, plant extracts, Prunella L

Abstract

In article there are results of antioxidant activity of water and water-alcohol extracts from aerial parts Prunella L. species: Prunella grandiflora L., Prunella laciniata L. and Prunella vulgaris L by in vitro and in vivo tests. The highest antioxidant activity was established to air-dried residues of water-alcohol extracts (solvent – 70 % ethanol) which inhibited generation of superoxide, hydroxyl- and DPPH-radicals and improved pro-oxidant antioxidant balance to animals without pathological forms. It was expressed in the increasing activity of endogenous antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, and the deceasing of TBARS.

Author Biography

A.A. Shamilov, Pyatigorsk Medical-Pharmaceutical Institute - Branch of Volgograd State Medical University (Pyatigorsk, Russia)

К.фарм.н., доцент кафедры фармакогнозии, ботаники и технологии фитопрепаратов

References

Free radicals, metals and antioxidants in oxidative stress-induced cancer / M. Valko, C. Rhodes, J. Moncol [et al.] // Chem Biol Interact. 2006; 160(1):1–40.

Oxidative Stress-Mediated Atherosclerosis: Mechanisms and Therapies / X. Yang, Y. Li, Y. Li [et al.] // Frontiers in Physiology. 2017; 8:600. doi:10.3389/fphys.2017.00600.

Pathophysiology and Treatments of Oxidative Injury in Ischemic Stroke: Focus on the Phagocytic NADPH Oxidase 2 / F. Carbone, P.C. Teixeira, V. Braunersreuther [et al.] // Antioxidants & Redox Signaling. 2015; 23(5): 460-489. doi:10.1089/ars.2013.5778.

Oxidative stress, fibrosis, and early afterdepolarization-mediated cardiac arrhythmias / H.S. Karagueuzian, T.P. Nguyen, Z. Qu [et al.] // Frontiers in Physiology. 2013; 4:19. doi:10.3389/fphys.2013.00019.

Gerber, P.A. The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus / P.A. Gerber, G.A. Rutter // Antioxidants & Redox Signaling. 2017; 26(10): 501-518. doi:10.1089/ars.2016.6755.

Natural Antioxidants in Foods and Medicinal Plants: Extraction, Assessment and Resources. Arr?ez-Rom?n D, G?mez Caravaca AM, eds. / D.-P. Xu, Y. Li, X. Meng [et al.] // International Journal of Molecular Sciences. 2017; 18(1):96. doi:10.3390/ijms18010096.

Poljsak, B. Achieving the Balance between ROS and Antioxidants: When to Use the Synthetic Antioxidants / B. Poljsak, D. ?uput, I. Milisav // Oxidative Medicine and Cellular Longevity. 2013;2013:956792. doi:10.1155/2013/956792.

Tao, Z. Epidemiological perspectives of diabetes / Z. Tao, A. Shi, J. Zhao // Cell Biochem Biophys. 2015;73:181–5.

A Review Study on Phytochemistry and Pharmacology Applications of Juglans Regia Plant / H. Delaviz, J. Mohammadi, G. Ghalamfarsa [et al.] // Pharmacognosy Reviews. 2017;11(22):145–152. doi:10.4103/phrev.phrev_10_17.

Попова, Н.В. Лекарственные растения мировой флоры / Н.В. Попова, В.Н. Литвиненко. – Харьков: СПДФЛ, 2008. – 510 с.

Бондаренко, О.М. Фенольные соединения черноголовки / О.М. Бондаренко, В.И. Литвиненко, П.П. Баланда // Современные проблемы фармацевтической науки и практики. – Киев, 1972. – С.730–731.

Растительные ресурсы России: Дикорастущие цветковые растения, их компонентный состав и биологическая активность. Т. 4. Семейство Caprifoliaceae – Lobeliaceae / Под ред. П.Д. Соколова. – СПб. – М.: Товарищество научных изданий КМК, 2011. – 630 с.

Дмитрук, С.И. Кумарины Prunella vulgaris / С.И. Дмитрук // Химия природ. соединений. – 1986. – №4. – С.510–511.

Шамилов, А.А. Поиск источников розмариновой кислоты во флоре Северного Кавказа / А.А. Шамилов, Н.В. Попова, М.Н. Ивашев // Современные проблемы науки и образования. – 2014. – №4. – С.644.

Antioxidant activity of Juglans nigra L. bark extract in the experiment / D.I. Pozdnyakov, D.S. Zolotykh, Z.H.V. Daironas [et al.] // Биорадикалы и антиоксиданты. – 2019. – Т. 6. – №. 1. – С.20–30.

Antihypoxic and anti-ischemic properties of the North Caucasus flora plant extracts / D.I. Pozdnyakov, A.E. Pozdnyakova, S.L. Adzhiahmetova [et al.] // Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas. – 2019. – Vol.18(5). – P.504–517.

Сравнение антиоксидантной активности мексидола при повреждениях головного мозга различного генеза в эксперименте / А.В. Воронков, Д.И. Поздняков, Е.И. Хури [и др.] // Современные проблемы науки и образования. – 2016. – Т.6. – С.12.

Флора СССР: в 30 т. Т. 20. Род 1261. Черноголовка м Prunella L. / Под ред. В.Л. Комарова. – М. – Л.: Изд-во АН СССР, 1954. – С.494–498.

Дикорастущие полезные растения России / Под. ред. А.Л. Буданцева, Е.Е. Лесиовской. – СПб.: Издательство СПХФА, 2001. – 663 с.

Шамилов А.А. Растения рода Prunella: Химический состав, виды фармакологического действия / А.А. Шамилов // Вестник Воронежского государственного университета. Серия: Химия. Биология. Фармация. – 2017. – №4. – С.152–160.

Parental use of the term «Hot Qi» to describe symptoms in their children in Hong Kong: a cross sectional survey «Hot Qi» in children / F.Y. Kong, D.K. Ng, C.H. Chan [et al.] // Journal of ethnobiology and ethnomedicine, 2006, 2(1), 2. doi: 10.1186/1746-4269-2-2.

Perera, P.K. Functional herbal food ingredients used in type 2 diabetes mellitus / P.K. Perera, Y. Li // Pharmacognosy reviews, 2012, 6 (11), 37-45. doi: 10.4103/0973-7847.95863

Ethnoveterinary medicines used for ruminants in British Columbia, Canada / C. Lans, N. Turner, T. Khan [et al.] // Journal of ethnobiology and ethnomedicine, 2007, 3(1), 11. doi: 10.1186/1746-4269-3-11.

Mittler, R. ROS are good / R. Mittler // Trends in plant science, 2017, 22 (1), 11-19. doi:10.1016/j.tplants.2016.08.002

Apak R. Current issues in antioxidant measurement / R. Apak // Journal of agricultural and food chemistry, 2019, 67(33), 9187-9202. doi:10.1021/acs.jafc.9b03657.

Published

2020-06-30

How to Cite

Shamilov А., Pozdnyakov Д., Bubenchikova Н., Chernikov М., and Garsiya Е. “Antioxidant Activity of Extracts from Species of Genus Prunella L.: In Vitro and in Vivo Investigation”. Traditional Medicine, no. 2(61) 2020, June 2020, pp. 40-46, http://www.tradmed.ru/index.php/tm/article/view/1511.

Issue

Section

Naturopathy

Most read articles by the same author(s)