Influence of local therapy by essential oils on dynamics of immune effects and hormonal levels in patients with osteoarthrosis

Abstract

The study involved 60 women patients with OA, divided into 2 comparable groups. In the first group of OA patients treated with applications of 5 % mix EM: lavender, ginger, peppermint, rosemary, pine, clove, nutmeg, eucalyptus, thyme, anise., in the control group was received diclofenac 100 mg per day. The results of the treatment were assessed before and after treatment on dynamics of clinical indicators: the index Lekena, the Likert scale. The dynamics of laboratory indicators of the General analysis and blood biochemistry were assessed before and after treatment. Changes in the state of total leukocytes, CD4+,CD8+, index CD4+/CD8+, CD19, IgG, IgA, IgM.And dynamic performance of the following hormones: STH, PL, cort., TTH, fT4, fT3, PTH, CT, OC, LH, FSH, E2 and T, DHEA-s, AS, PG, INS, С-P, index HOMA-IR were studied before and after treatment. Before treatment, both groups showed immunodeficiency CD4, increased CD8 cytotoxic cells, reducing the index of CD4+/CD8+. After a course of therapy with applications of EM showed an increase of CD4, CD8 decrease, the increase of the CD4+/CD8+. The marked increase in testosterone (p < 0.05), decreased level of insulin , glucose (p < 0.05) and HOMA-IR (p < 0.05). In the control group dynamics of the immune and hormonal systems are not marked. The effectiveness of treatment was higher in the group of patients treated with applications of EM according to the index Lekena, Likert scale, p < 0.02, compared with the control group index that have been Identified, the Likert scale, p < 0.05.