Substantiation of technology and standardization of syrup based on a liquid extract from the herb of melissa officinalis (Melissa officinalis L.)
DOI:
https://doi.org/10.54296/18186173_2025_2_31Keywords:
Melissa officinalis L., herb, liquid extract, syrups, technology, standardization, rosmarinic acid, sucrose, sorbitolAbstract
Currently, the development of domestic drugs for children plays an important role in modern pharmacy.
A promising plant in this regard is Melissa officinalis L.
A number of valuable pharmacological properties allow the use of drugs based on the herb of Melissa officinalis to alleviate various conditions in children.
Syrups are one of the most common and convenient dosage forms used in pediatric practice. As a pharmaceutical substance was used a liquid extract (1:1), obtained from the herb of Melissa officinalis on the based of 40% ethyl alcohol and containing a sum of phenylpropanoids of 1.12 ± 0.05 % (in terms of rosmarinic acid).
Technologically, 6 samples of syrups based on sucrose and sorbitol were prepared with the addition of 1 %, 2 %, 3 % liquid extract.
It was determined, that the content of the sum of phenylpropanoids (in terms of rosmarinic acid) in samples of sugar syrups with the addition of 1 %, 2 %, 3 % liquid extract in 40 % ethyl alcohol is 0,011 ± 0,001 %; 0,024 ± 0,002 %; 0,036 ± 0,002 % accordingly. The amount of phenylpropanoids (in terms of rosmarinic acid) in samples of sorbitol syrups with the addition of 1 %, 2 %, 3 % liquid extract in 40 % ethyl alcohol is 0,011 ± 0,001 %; 0,021 ± 0,001 %; 0,032 ± 0,002 % accordingly.
As a result of the research, the technology and approaches to standardization of syrup based on a liquid extract from the herb of Melissa officinalis L. have been substantiated.
A method has been developed for quantifying the amount of phenylpropanoids (in terms of rosmarinic acid) in sugar or sorbitol syrup with the addition of 1 %, 2 % and 3 % liquid extract in 40 % ethyl alcohol from the herb of Melissa officinalis.
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